Document Detail

Local relation between oxidative metabolism and perfusion in leg muscles of patients with heart failure studied by magnetic resonance imaging and spectroscopy.
MedLine Citation:
PMID:  9773862     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We studied the local relation of muscle perfusion and metabolism in patients with severe chronic heart failure. Alterations of skeletal muscle blood flow and oxidative capacity contribute to exercise intolerance in these patients. The interdependence of both parameters has often been questioned. METHODS AND RESULTS: With the use of nuclear magnetic resonance, we quantified leg and muscle perfusion during reactive hyperemia in 7 patients with heart failure (New York Heart Association class III and IV) and 7 age-matched control subjects from the difference in longitudinal relaxation rate (1/T1). By using 31P nuclear magnetic resonance spectroscopy, we assessed oxidative metabolism from the creatine rephosphorylation time constant after a short ischemic exercise. Phosphocreatine recovery is slowed (74.6 +/- 11.3 vs 49.9 +/- 13.9 seconds, p = .002) and reactive hyperemic flow is reduced (48.5 +/- 24.9 vs 113 +/- 30.4 mL/100 mL per minute, p = .0005). CONCLUSIONS: By using a totally noninvasive protocol, we demonstrated that reactive hyperemic flow correlates with oxidative capacity in calf muscles from patients with heart failure, showing that exercise performance and local circulatory dysfunction are decreased in parallel in severe heart failure.
J F Toussaint; T M Koelling; C J Schmidt; K K Kwong; P J LaRaia; H L Kantor
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  17     ISSN:  1053-2498     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-12-22     Completed Date:  1998-12-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  892-900     Citation Subset:  IM    
Service de Physiologie et de Radioisotopes, Hôpital Broussais, Paris.
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MeSH Terms
Chronic Disease
Exercise Tolerance / physiology
Heart Failure / physiopathology*
Magnetic Resonance Imaging*
Magnetic Resonance Spectroscopy*
Middle Aged
Muscle, Skeletal / blood supply*,  metabolism*
Oxidative Phosphorylation
Phosphocreatine / metabolism
Regional Blood Flow
Reg. No./Substance:

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