Document Detail

Local regulation of homeostasis favors chromosomal instability.
MedLine Citation:
PMID:  12676089     Owner:  NLM     Status:  MEDLINE    
Tissues of long-lived multicellular organisms have to maintain a constant number of functioning cells for many years. This process is called homeostasis. Homeostasis breaks down when cells emerge with mutations in tumor suppressor genes or oncogenes. Such mutated cells can have increased net rates of proliferation, which is increased somatic fitness. We show that the best protection against such mutations is achieved when homeostasis is regulated locally via small compartments. Small compartments, on the other hand, allow the accumulation of cells with reduced somatic fitness. Cells with mutations conferring genetic instability normally have a reduced somatic fitness because they have an increased probability of producing deleterious mutations or triggering apoptosis. Thus, small compartments protect against mutations in tumor suppressor genes or oncogenes but promote the emergence of genetic instability.
Franziska Michor; Yoh Iwasa; Natalia L Komarova; Martin A Nowak
Related Documents :
19443409 - Mutation analysis of igvh genes in splenic marginal zone lymphomas: correlation with cl...
17640729 - Genomic analysis of cd8+ nk/t cell line, 'srik-nkl', with array-based cgh (acgh), sky/f...
19380639 - Tnfaip3 (a20) is a tumor suppressor gene in hodgkin lymphoma and primary mediastinal b ...
24700299 - The frequencies and clinical implications of mutations in 33 kinase-related genes in lo...
23620769 - Protein arginine methyltransferase 1 and 8 interact with fus to modify its sub-cellular...
6300689 - Somatic generation of antibody diversity.
23440589 - Genetic genealogy comes of age: perspectives on the use of deep-rooted pedigrees in hum...
14994919 - Mthfr c677t mutation, factor ii g20210a mutation and factor v leiden as risks factor fo...
12456349 - Retroviral mutation rates and reverse transcriptase fidelity.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current biology : CB     Volume:  13     ISSN:  0960-9822     ISO Abbreviation:  Curr. Biol.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-04     Completed Date:  2003-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  581-4     Citation Subset:  IM    
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Transformation, Neoplastic / genetics
Chromosome Disorders / genetics*
Genes, Tumor Suppressor / physiology*
Homeostasis / genetics*,  physiology*
Loss of Heterozygosity / genetics
Models, Genetic
Models, Theoretical
Mutation / genetics*,  physiology
Oncogenes / genetics,  physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Telomere maintenance in fission yeast requires an Est1 ortholog.
Next Document:  Stimulus-driven and voluntary saccades are coded in different coordinate systems.