Document Detail


Local radiant heating increases subcutaneous oxygen tension.
MedLine Citation:
PMID:  9445236     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: We evaluated a novel bandage that incorporates a thermostatically controlled radiant heater. We first determined optimal bandage temperature, based on increases in subcutaneous oxygen tension, a measure correlating well with resistance to infection and wound strength. We then tested the hypothesis that prolonged radiant heating would increase collagen deposition in experimental thigh wounds. METHODS: The experimental bandages were positioned on the anterior thigh of 8 volunteers, and heated for 2 hours at 38 degrees C, 42 degrees C, or 46 degrees C, in a random order. Subcutaneous oxygen tension under the bandage was recorded from an electrode positioned within a subcutaneous tonometer. We studied 10 volunteers in the second protocol. For 1 week, the experimental bandage was continuously applied to one thigh, and heated to 38 degrees C using a 2-hour on/off cycle. On the alternate week, a standard gauze bandage was applied to the contralateral thigh. Treatment order was randomly assigned. Wound collagen deposition under each bandage was evaluated with subcutaneous polytetrafluoroethylene tubes, which were removed and assayed for hydroxyproline on the eighth day. Data are presented as means +/- SDs. RESULTS: Skin temperature during heating ranged from 36 degrees C to 37.5 degrees C. Oxygen tension increased approximately 50% during heating, but the increase was comparable at the three tested temperatures. Even after heating was discontinued, subcutaneous oxygen tension remained elevated for the remaining 3 study hours. Collagen deposition after 1 week of active heating was 3.4 +/- 1.0 microg/ cm. After 1 week of control treatment, collagen deposition was 3.2 +/- 1.1 microg/cm (P = not significant). CONCLUSIONS: Our data suggest that radiant heating at 38 degrees C significantly increases subcutaneous oxygen tension, and presumably resistance to infection. However, prolonged heating at this temperature does not increase wound collagen deposition.
Authors:
T Ikeda; F Tayefeh; D I Sessler; A Kurz; O Plattner; B Petschnigg; H W Hopf; J West
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of surgery     Volume:  175     ISSN:  0002-9610     ISO Abbreviation:  Am. J. Surg.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-09     Completed Date:  1998-02-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  33-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesia and Perioperative Care, University of California, San Francisco, 94143-0648, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bandages*
Chromatography, High Pressure Liquid
Collagen / metabolism*
Female
Hot Temperature*
Humans
Hydroxyproline / analysis
Male
Oxygen / metabolism*
Skin Temperature* / physiology
Surgical Wound Infection / prevention & control
Thigh
Time Factors
Wound Healing
Wounds and Injuries / metabolism*
Grant Support
ID/Acronym/Agency:
GM49670/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
51-35-4/Hydroxyproline; 7782-44-7/Oxygen; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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