Document Detail

Local nasal immunotherapy with extract in powder form is effective and safe in grass pollen rhinitis: a double-blind study.
MedLine Citation:
PMID:  8568135     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Local nasal immunotherapy has been studied, by means of an extract in powder form, in patients with allergic rhinitis caused by grass pollen. METHODS: Thirty-two patients allergic to grass were studied for 37 weeks in a double-blind controlled trial. Subjects were selected on the basis of a positive history, skin test result, RAST finding, and result of intranasal challenge to grass pollen. Two 16-patient groups were randomly assigned to active or placebo treatment. The treatment lasted 26 weeks (14 for the build-up phase, 12 for the maintenance period). RESULTS: No significant differences were observed in nasal symptoms during the treatment. During the pollen season the mean weekly symptom and medication scores were significantly lower in the treated group, compared with the control group, even considering each allergic symptom separately. Moreover, only in the treated group was a significant increase of specific nasal threshold to grass pollen observed after treatment. CONCLUSIONS: This study indicates that local nasal immunotherapy with allergen in powder form can be a suitable alternative to the traditional subcutaneous immunotherapy in terms of clinical efficacy and safety in grass-allergic rhinitis.
L Andri; G Senna; C Betteli; S Givanni; G Andri; G Dimitri; P Falagiani; P Mezzelani
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  97     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-03-06     Completed Date:  1996-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  34-41     Citation Subset:  AIM; IM    
Unit of Clinical Allergology, Verona General Hospital, Italy.
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MeSH Terms
Administration, Intranasal
Allergens / administration & dosage*
Desensitization, Immunologic*
Double-Blind Method
Pollen / immunology*
Radioallergosorbent Test
Rhinitis, Allergic, Seasonal / etiology,  immunology,  therapy*
Skin Tests
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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