| Local intra-arterial fibrinolytic therapy in patients with stroke: urokinase versus recombinant tissue plasminogen activator (r-TPA). | |
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MedLine Citation:
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PMID: 8433796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A group of 59 patients with stroke due to acute vertebrobasilar or carotid territory occlusion have been treated by local intra-arterial fibrinolysis (LIF). A high recanalisation rate was accomplished with either urokinase or recombinant tissue plasminogen activator (r-TPA). However, with either substance, even if a high dose was used, recanalisation was a time-consuming process which usually took 120 min. A reasonable explanation for the lack of effectiveness of these plasminogen-activating substances might be a deficit of substrate, e.g. plasminogen, in aged thrombus. LIF was capable of improving clinical outcome in acute vertebrobasilar artery occlusion, reducing mortality to 50% in patients fulfilling inclusion criteria. In the carotid territory multiple occlusions had a poor prognosis while good clinical results could be achieved in occlusions of the proximal middle cerebral artery or single branches. |
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Authors:
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H Zeumer; H J Freitag; F Zanella; A Thie; C Arning |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroradiology Volume: 35 ISSN: 0028-3940 ISO Abbreviation: Neuroradiology Publication Date: 1993 |
Date Detail:
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Created Date: 1993-03-18 Completed Date: 1993-03-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 1302751 Medline TA: Neuroradiology Country: GERMANY |
Other Details:
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Languages: eng Pagination: 159-62 Citation Subset: IM |
Affiliation:
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Department of Neuroradiology, University Hospital Eppendorf, Hamburg, Federal Republic of Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carotid Artery Thrombosis
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drug therapy Cerebrovascular Disorders / drug therapy*, etiology, radiography Humans Intracranial Embolism and Thrombosis / drug therapy Radiography, Interventional Thrombolytic Therapy* / adverse effects, methods Urokinase-Type Plasminogen Activator / therapeutic use* Vertebrobasilar Insufficiency / drug therapy |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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