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Local intra-arterial fibrinolysis in acute basilar artery occlusion.
MedLine Citation:
PMID:  20566075     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Summary: Acute basilar artery (BA) occlusion is typically associated with poor outcome; however newer diagnostic and treatment modalities have the potential to improve prognosis. In this study, six patients with acute BA occlusion were followed and the effectiveness of local intra-arterial fibrinolysis (LIF) and subsequent percutaneous transluminal angioplasty (PTA) with a balloon catheter were assessed. Of the six patients with BA occlusion observed in this study, two had extended brain stem infarction on diffusion weighted image (DWI) and were treated conservatively. The other four patients received LIF at an average of 5.2 hours from occlusion onset. Three of these four patients received additional PTA with compliant balloon catheters. All four of the patients who received LIF achieved recanalization of the BA trunk and showed a favorable clinical outcome. These findings suggest that LIF is beneficial for selected patients with BA occlusion and that successful recanalization is indicative of a good prognosis. Because of the poor prognosis associated with conservative therapy, we conclude that LIF should be attempted even for comatose patients or in cases of prolonged occlusion time.
Authors:
Y Enomoto; S Yoshimura; H Kitajima; N Tamakawa; T Iwama
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Publication Detail:
Type:  Journal Article     Date:  2007-06-27
Journal Detail:
Title:  Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences     Volume:  13 Suppl 1     ISSN:  1591-0199     ISO Abbreviation:  Interv Neuroradiol     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2010-06-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602695     Medline TA:  Interv Neuroradiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  44-7     Citation Subset:  -    
Affiliation:
Department of Neurosurgery, Graduate School of Medicine, Gifu University, Gifu, Japan.
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