Document Detail


Local interrelationships of cerebral oxygen consumption and glucose utilization in normal subjects and in ischemic stroke patients: a positron tomography study.
MedLine Citation:
PMID:  6609928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
With the use of positron emission tomography (PET) and the 15O steady-state-[18F]fluorodeoxyglucose combined method, the local interrelationships between the cerebral metabolic rate for oxygen (CMRO2) and the cerebral metabolic rate for glucose ( CMRGlc ) were investigated in control subjects and in stroke patients. In addition to the classic in vivo autoradiographic approach, a kinetic method was used to measure CMRGlc because it was expected to be more reliable in cerebral ischemia. In control subjects local coupling between CBF, CMRO2, and CMRGlc was confirmed, and acceptable values for the CMRO2/ CMRGlc ratio were found; the latter, however, was lower in white matter than in gray. Uncoupling between CMRO2 and CMRGlc was observed in all stroke patients, suggesting that (1) enhanced anaerobic glycolysis occurred both in reperfused recent infarcts and in chronically ischemic tissue, and (2) substrates other than blood-borne glucose were being oxidized at the borders of recent infarcts. However, methodological uncertainties presently make such observations only tentative. Finally, a coupled depression of CMRO2 and CMRGlc was found in the contralateral cerebellum.
Authors:
J C Baron; D Rougemont; F Soussaline; P Bustany; C Crouzel; M G Bousser; D Comar
Related Documents :
12107528 - Effects of intravenous administration of prostaglandin e(1) and lipo-prostaglandin e(1)...
7808608 - Long-term surface cortical cerebral blood flow monitoring in temporal lobe epilepsy.
6701938 - The prognostic value of noninvasive cbf measurement in subarachnoid hemorrhage.
19794398 - Pharmacological uncoupling of activation induced increases in cbf and cmro2.
19428108 - Effects of various propolis concentrations on biochemical and hematological parameters ...
9316888 - Evaluation of pcr for diagnosis of visceral leishmaniasis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  4     ISSN:  0271-678X     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-06-22     Completed Date:  1984-06-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  140-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Brain / metabolism*,  radionuclide imaging
Cerebellum / metabolism
Cerebrovascular Circulation
Cerebrovascular Disorders / metabolism*,  radionuclide imaging
Female
Glucose / metabolism*
Humans
Ischemic Attack, Transient / metabolism*,  radionuclide imaging
Male
Middle Aged
Oxygen Consumption*
Tomography, Emission-Computed*
Chemical
Reg. No./Substance:
50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Differential protein insertion into developing photosynthetic membrane regions of Rhodopseudomonas s...
Next Document:  Regional kinetic constants and cerebral metabolic rate for glucose in normal human volunteers determ...