Document Detail

Local injection into mimetic muscles of botulinum toxin A for the treatment of facial lines.
MedLine Citation:
PMID:  9374139     Owner:  NLM     Status:  MEDLINE    
The purpose of this clinical investigation is to confirm the efficacy of eliminating facial wrinkles by injecting botulinum toxin A into mimetic muscles. Fifty-four patients were injected with BOTOX A-14 in the corrugator superciliaris, 19 in the frontalis muscles, and 13 in the orbicularis oculis. Dilution was obtained by adding 4 ml preservative-free saline to 100 IU of BOTOX A. The dose used varied according to the patient. The severity of wrinkles and the intensity of muscle contraction (facial expression) were taken into account. The paralysis obtained in the mimetic muscles was effective for 6 months in 39 patients, 8 months in 10 patients, and 9 months in 1 patient. The results were documented by photographs, videotape, and electromyographies pre- and postinjection. To preserve the results, 21 patients (39%) demanded a second infiltration to achieve satisfactory results. Neither local nor general adverse effects were noted, except transitory eyebrow palsy in 2 patients, and edema and ecchymosis in 4 patients. The improvement obtained in facial mimetic wrinkles was satisfactory to the patient and to us.
J Guerrissi; P Sarkissian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of plastic surgery     Volume:  39     ISSN:  0148-7043     ISO Abbreviation:  Ann Plast Surg     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-12-19     Completed Date:  1997-12-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7805336     Medline TA:  Ann Plast Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  447-53     Citation Subset:  IM    
Service of Plastic Surgery, Argerich Hospital, Buenos Aires, Argentina.
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MeSH Terms
Botulinum Toxin Type A / administration & dosage*
Facial Muscles* / drug effects
Injections, Intramuscular
Middle Aged
Muscle Contraction / drug effects
Neuromuscular Agents / administration & dosage*
Skin Aging*
Reg. No./Substance:
0/Botulinum Toxin Type A; 0/Neuromuscular Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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