Document Detail

Local infusion of the nitric oxide donor Sin-1 after angioplasty. Effects on intimal hyperplasia in porcine coronary arteries.
MedLine Citation:
PMID:  12846690     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the development of intimal hyperplasia in response to percutaneous transluminal coronary angioplasty (PTCA) followed by local delivery of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1). MATERIAL AND METHODS: Overdilation PTCA was performed in coronary arteries in 20 healthy pigs. One of the dilated segments was additionally treated with local delivery of SIN-1 for 10 min. Segments distal to the treated part of the arteries served as controls. Arteries were radiographically depicted and analyzed after 1 and 8 weeks for actin, myosin and intermediate filaments (IF), nitric oxide synthetase (NOS) and histological evaluation. RESULTS: Segments treated with PTCA+SIN-1 showed a significantly (p=0.03) larger luminal diameter compared with PTCA only treated segments. The luminal loss after SIN-1 was not significant compared with the diameter prior to treatment. Endothelial NOS content was significantly lower in the PTCA+SIN-1 group compared with the PTCA group after 1 (p=0.03) and 8 weeks (p=0.013). IF/actin ratio after 1 week was significantly increased in PTCA-treated segments compared with untreated controls (p=0.004), and compared with PTCA+SIN-1-treated segments (p=0.004). CONCLUSION: PTCA-induced intimal hyperplasia was potently inhibited by local delivery of the NO donor SIN-1. Momentary events at the time of injury play a significant role in the development of intimal hyperplasia and long-lasting down-regulation of the endothelial NOS expression after SIN-1 exposure is suggested. The IF/actin ratio can be useful as an early marker of intimal hyperplasia.
J Harnek; E Zoucas; R Sjuve; A Arner; E Ekblad; H Schou; V Perez de Sá; U Stenram
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  44     ISSN:  0284-1851     ISO Abbreviation:  Acta Radiol     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-08     Completed Date:  2003-08-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  395-402     Citation Subset:  IM    
Heart Lung Division, Heart Radiology, University Hospital Lund, Lund, Sweden.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Coronary Restenosis / prevention & control*
Coronary Vessels / pathology
Molsidomine / administration & dosage*,  analogs & derivatives*,  pharmacology
Nitric Oxide Donors / administration & dosage*,  pharmacology
Nitric Oxide Synthase / metabolism
Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors
Tunica Intima / pathology*
Reg. No./Substance:
0/Nitric Oxide Donors; 25717-80-0/Molsidomine; 33876-97-0/3-morpholino-sydnonimine; EC Oxide Synthase; EC ATPase

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