| Local immune reaction in nasopharyngeal carcinoma, with special reference to its prognostic evaluation. | |
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MedLine Citation:
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PMID: 2479615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study of the tumor-host interaction was conducted in 30 patients with nasopharyngeal carcinoma (NPC). The local immune reaction was investigated by an immunoperoxidase technique using monoclonal antibodies. Eighteen patients who were clinically suspected to have NPC, but finally proved otherwise, served as controls. There was a significant difference between the number of NPC patients with interleukin-2 receptor (IL-2R)-positive cells (activated T lymphocytes) in the stroma compared with the control. IL-2R positive cells were found in 67% of NPC patients but in only 22% of controls (P less than 0.01). There was a greater infiltration of T lymphocytes in patients with a good outcome compared with patients with a poor outcome. This trend was observed in both the parenchyma (60.2 versus 29.4 x 10(4) cells/mm2) and the stroma (74.7 versus 44.8 x 10(4) cells/mm2). The levels of Leu-3 positive cells (helper/inducer) in the NPC parenchyma were inversely correlated to the extent of the primary tumor, but there was no correlation in the stroma. These findings demonstrate that a local host-immune reaction does exist and may be a useful prognostic indicator for NPC patients. |
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Authors:
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M M Hsu; H C Hsu; L T Lui |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Head & neck Volume: 11 ISSN: 1043-3074 ISO Abbreviation: Head Neck Publication Date: 1989 Nov-Dec |
Date Detail:
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Created Date: 1989-12-22 Completed Date: 1989-12-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8902541 Medline TA: Head Neck Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 505-10 Citation Subset: IM |
Affiliation:
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Department of Otolarynoglogy, College of Medicine, National Taiwan University, Taipei, Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biopsy Female Humans Immunity, Cellular Male Middle Aged Nasopharyngeal Neoplasms / immunology*, pathology Prognosis Receptors, Interleukin-2 / immunology* Staining and Labeling T-Lymphocytes / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Interleukin-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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