Document Detail

Local immune reaction in nasopharyngeal carcinoma, with special reference to its prognostic evaluation.
MedLine Citation:
PMID:  2479615     Owner:  NLM     Status:  MEDLINE    
A study of the tumor-host interaction was conducted in 30 patients with nasopharyngeal carcinoma (NPC). The local immune reaction was investigated by an immunoperoxidase technique using monoclonal antibodies. Eighteen patients who were clinically suspected to have NPC, but finally proved otherwise, served as controls. There was a significant difference between the number of NPC patients with interleukin-2 receptor (IL-2R)-positive cells (activated T lymphocytes) in the stroma compared with the control. IL-2R positive cells were found in 67% of NPC patients but in only 22% of controls (P less than 0.01). There was a greater infiltration of T lymphocytes in patients with a good outcome compared with patients with a poor outcome. This trend was observed in both the parenchyma (60.2 versus 29.4 x 10(4) cells/mm2) and the stroma (74.7 versus 44.8 x 10(4) cells/mm2). The levels of Leu-3 positive cells (helper/inducer) in the NPC parenchyma were inversely correlated to the extent of the primary tumor, but there was no correlation in the stroma. These findings demonstrate that a local host-immune reaction does exist and may be a useful prognostic indicator for NPC patients.
M M Hsu; H C Hsu; L T Lui
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Head & neck     Volume:  11     ISSN:  1043-3074     ISO Abbreviation:  Head Neck     Publication Date:    1989 Nov-Dec
Date Detail:
Created Date:  1989-12-22     Completed Date:  1989-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  505-10     Citation Subset:  IM    
Department of Otolarynoglogy, College of Medicine, National Taiwan University, Taipei, Republic of China.
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MeSH Terms
Immunity, Cellular
Middle Aged
Nasopharyngeal Neoplasms / immunology*,  pathology
Receptors, Interleukin-2 / immunology*
Staining and Labeling
T-Lymphocytes / immunology*
Reg. No./Substance:
0/Receptors, Interleukin-2

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