Document Detail

Local hyperthermia induces apoptosis of keratinocytes in both normal skin and condyloma acuminata via different pathways.
MedLine Citation:
PMID:  19363704     Owner:  NLM     Status:  MEDLINE    
Local hyperthermia has been successfully used in the treatment of viral warts. However, the mechanism of action of hyperthermia has largely remained unclear. In this study we evaluated the effect of local hyperthermia on the induction of apoptosis in human keratinocytes, and expression of apoptosis-related genes in both condyloma acuminata (CA) and normal skin. The study showed that higher hyperthermia increased the number of apoptotic keratinocytes in CA and normal skin. The temperature-dependent increased expression of Fas and Bax were observed in both CA and normal skin. In contrast, the expression of Bcl-2 in CA was decreased at both transcriptional and translational levels. Furthermore, the transcriptional expression of DR4 and DR5 were increased in a temperature-dependent manner in CA, but not in normal skin. These results suggest that different mechanisms of action might be involved in hyperthermia induced apoptosis in CA and normal skin.
Xiaoqin Wang; Xing-Hua Gao; Xiaodong Li; Yuxiao Hong; Ruiqun Qi; Hong-Duo Chen; Li Zhang; Huachen Wei
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Apoptosis : an international journal on programmed cell death     Volume:  14     ISSN:  1573-675X     ISO Abbreviation:  Apoptosis     Publication Date:  2009 May 
Date Detail:
Created Date:  2010-04-27     Completed Date:  2010-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9712129     Medline TA:  Apoptosis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  721-8     Citation Subset:  IM    
Department of Dermatology, No. 1 Hospital of China Medical University, 110001 Shenyang, China.
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MeSH Terms
Alphapapillomavirus / classification
Apoptosis* / genetics
Apoptosis Regulatory Proteins / genetics,  metabolism
Cell Nucleus / metabolism
Condylomata Acuminata / metabolism,  pathology*,  virology
Gene Expression Regulation
Hyperthermia, Induced / methods*
Keratinocytes / pathology*
RNA, Messenger / genetics,  metabolism
Signal Transduction*
Skin / pathology*
Transcription, Genetic
Reg. No./Substance:
0/Apoptosis Regulatory Proteins; 0/RNA, Messenger

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