| Local hyperthermia induces apoptosis of keratinocytes in both normal skin and condyloma acuminata via different pathways. | |
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MedLine Citation:
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PMID: 19363704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Local hyperthermia has been successfully used in the treatment of viral warts. However, the mechanism of action of hyperthermia has largely remained unclear. In this study we evaluated the effect of local hyperthermia on the induction of apoptosis in human keratinocytes, and expression of apoptosis-related genes in both condyloma acuminata (CA) and normal skin. The study showed that higher hyperthermia increased the number of apoptotic keratinocytes in CA and normal skin. The temperature-dependent increased expression of Fas and Bax were observed in both CA and normal skin. In contrast, the expression of Bcl-2 in CA was decreased at both transcriptional and translational levels. Furthermore, the transcriptional expression of DR4 and DR5 were increased in a temperature-dependent manner in CA, but not in normal skin. These results suggest that different mechanisms of action might be involved in hyperthermia induced apoptosis in CA and normal skin. |
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Authors:
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Xiaoqin Wang; Xing-Hua Gao; Xiaodong Li; Yuxiao Hong; Ruiqun Qi; Hong-Duo Chen; Li Zhang; Huachen Wei |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Apoptosis : an international journal on programmed cell death Volume: 14 ISSN: 1573-675X ISO Abbreviation: Apoptosis Publication Date: 2009 May |
Date Detail:
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Created Date: 2010-04-27 Completed Date: 2010-07-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9712129 Medline TA: Apoptosis Country: United States |
Other Details:
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Languages: eng Pagination: 721-8 Citation Subset: IM |
Affiliation:
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Department of Dermatology, No. 1 Hospital of China Medical University, 110001 Shenyang, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alphapapillomavirus
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classification Apoptosis* / genetics Apoptosis Regulatory Proteins / genetics, metabolism Cell Nucleus / metabolism Condylomata Acuminata / metabolism, pathology*, virology Female Gene Expression Regulation Humans Hyperthermia, Induced / methods* Immunohistochemistry Keratinocytes / pathology* Male RNA, Messenger / genetics, metabolism Serotyping Signal Transduction* Skin / pathology* Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Apoptosis Regulatory Proteins; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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