Document Detail

Local histamine H(1-) and H(2)-receptor blockade reduces postexercise skeletal muscle interstitial glucose concentrations in humans.
MedLine Citation:
PMID:  20962917     Owner:  NLM     Status:  MEDLINE    
Elevated blood flow can potentially influence skeletal muscle glucose uptake, but the impact of postexercise hyperemia on glucose availability to skeletal muscle remains unknown. Because postexercise hyperemia is mediated by histamine H(1)- and H(2)-receptors, we tested the hypothesis that postexercise interstitial glucose concentrations would be lower in the presence of combined H1- and H2-receptor blockade. To this end, 4 microdialysis probes were inserted into the vastus lateralis muscle of 14 healthy subjects (21-27 years old) immediately after 60 min of either upright cycling at 60% peak oxygen uptake (exercise, n = 7) or quiet rest (sham, n = 7). Microdialysis probes were perfused with a modified Ringer's solution containing 3 mmol L(-1) glucose, 5 mmol L(-1) ethanol, and [6-3H] glucose (200 disintegrations·min-1 microL(-1)). Two sites (blockade) received both H1- and H2-receptor antagonists (1 mmol L(-1) pyrilamine and 3 mmol L-1 cimetidine) and 2 sites (control) did not receive antagonists. Ethanol outflow/inflow ratios (an inverse surrogate of local blood flow) were higher in blockade sites than in control sites following exercise (p < 0.05), whereas blockade had no effect on ethanol outflow/inflow ratios following sham (p = 0.80). Consistent with our hypothesis, during 3 of the 5 dialysate collection periods, interstitial glucose concentrations were lower in blockade sites vs. control sites following exercise (p < 0.05), whereas blockade had no effect on interstitial glucose concentrations following sham (p = 0.79). These findings indicate that local H1- and H2-receptor activation modulates skeletal muscle interstitial glucose levels during recovery from exercise in humans and suggest that the availability of glucose to skeletal muscle is enhanced by postexercise hyperemia.
Thomas K Pellinger; Grant H Simmons; David A Maclean; John R Halliwill
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme     Volume:  35     ISSN:  1715-5312     ISO Abbreviation:  Appl Physiol Nutr Metab     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-21     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  617-26     Citation Subset:  IM    
Department of Human Physiology, University of Oregon, Eugene, OR 97403-1240, USA.
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MeSH Terms
Cimetidine / administration & dosage*
Ethanol / administration & dosage,  pharmacokinetics
Exercise / physiology*
Extracellular Space / metabolism
Glucose / administration & dosage,  pharmacokinetics*
Histamine H1 Antagonists / administration & dosage*
Histamine H2 Antagonists / administration & dosage*
Hyperemia / metabolism
Pyrilamine / administration & dosage*
Quadriceps Muscle* / blood supply,  drug effects,  metabolism
Receptors, Histamine H1 / metabolism
Receptors, Histamine H2 / metabolism
Tritium / diagnostic use
Young Adult
Reg. No./Substance:
0/Histamine H1 Antagonists; 0/Histamine H2 Antagonists; 0/Receptors, Histamine H1; 0/Receptors, Histamine H2; 10028-17-8/Tritium; 50-99-7/Glucose; 51481-61-9/Cimetidine; 64-17-5/Ethanol; 91-84-9/Pyrilamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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