| Local haemodynamics of arterial bypass graft anastomoses. | |
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MedLine Citation:
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PMID: 10581967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One of the main causes of failure of expanded polytetrafluoroethylene (PTFE) bypass grafts used in the lower limbs is the development of myointimal hyperplasia (MIH). Clinical studies show that higher patency rates can be obtained with the use of an autologous vein cuff (the Miller cuff) interposed between the graft and artery. The reasons for the improved performance are still unclear, but preliminary studies suggest that the change in local haemodynamics due to the cuff geometry may be the significant factor rather than the presence of autologous material. If this is the case, then PTFE grafts can be produced with an integral cuff, i.e. a precuffed graft, with similar haemodynamic patterns to that of the Miller cuff. In this paper, two different types of precuffed graft are presented and their flow patterns are compared with those recorded in the Miller cuff and the conventional end-to-side anastomosis. The haemodynamic studies were carried out using optically clear silicone rubber models under simulated in vivo pulsatile flow conditions. Flow structures similar to those observed in the Miller cuff were seen in the precuffed grafts. |
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Authors:
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C S Rowe; T K Carpenter; T V How; P L Harris |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine Volume: 213 ISSN: 0954-4119 ISO Abbreviation: Proc Inst Mech Eng H Publication Date: 1999 |
Date Detail:
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Created Date: 1999-12-23 Completed Date: 1999-12-23 Revised Date: 2009-06-08 |
Medline Journal Info:
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Nlm Unique ID: 8908934 Medline TA: Proc Inst Mech Eng H Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 401-9 Citation Subset: IM |
Affiliation:
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Department of Clinical Engineering, University of Liverpool, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anastomosis, Surgical
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methods,
statistics & numerical data Arteries / physiology*, surgery* Blood Flow Velocity / physiology Blood Vessel Prosthesis* / statistics & numerical data Blood Vessel Prosthesis Implantation / methods*, statistics & numerical data Humans Models, Cardiovascular Polytetrafluoroethylene Prosthesis Design / methods, statistics & numerical data Silicone Elastomers Stress, Mechanical Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Silicone Elastomers; 9002-84-0/Polytetrafluoroethylene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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