| Local glucocorticoid production in the mouse lung is induced by immune cell stimulation. | |
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MedLine Citation:
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PMID: 22111694 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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To cite this article: Hostettler N, Bianchi P, Gennari-Moser C, Kassahn D, Schoonjans K, Corazza N, Brunner T. Local glucocorticoid production in the mouse lung is induced by immune cell stimulation. Allergy 2011; DOI: 10.1111/j.1398-9995.2011.02749.x ABSTRACT: Background: Glucocorticoids (GC) are potent anti-inflammatory and immunosuppressive steroid hormones, mainly produced by the adrenal glands. However, increasing evidence supports the idea of additional extra-adrenal sources of bioactive GC. The lung epithelium is constantly exposed to a plethora of antigenic stimuli, and local GC synthesis could contribute to limit uncontrolled immune reactions and tissue damage. Methods: Expression of steroidogenic enzymes and GC synthesis in ex vivo organ cultures was studied in mouse lung tissue after in vivo stimulation of immune cells. Results: Mouse lung tissue was found to express steroidogenic enzymes required for the synthesis of corticosterone from cholesterol and to synthesize corticosterone in large quantities after immune cell activation by anti-CD3 antibody, lipopolysaccharide, or TNFα. In marked contrast, ovalbumin-induced allergic airway inflammation failed to promote lung GC synthesis. Although the lung expresses all steroidogenic enzymes necessary for de novo synthesis of corticosterone from cholesterol, functional data indicated that inactive serum-derived dehydrocorticosterone is converted to active corticosterone by 11β-hydroxysteroid dehydrogenase 1. Conclusion: Our results support the notion that local GC synthesis represents a novel immunoregulatory mechanism to limit uncontrolled immune responses in the lung and indicate that defective local steroidogenesis may contribute to the pathogenesis of allergic airway inflammation. |
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Authors:
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N Hostettler; P Bianchi; C Gennari-Moser; D Kassahn; K Schoonjans; N Corazza; T Brunner |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-24 |
Journal Detail:
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Title: Allergy Volume: - ISSN: 1398-9995 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804028 Medline TA: Allergy Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Division of Experimental Pathology, Institute of Pathology, University of Bern, Bern Department of Nephrology/Hypertension, University Hospital Bern, Bern Laboratory of Integrative and Systems Physiology, École Polytechnique Fédéral de Lausanne, Lausanne, Switzerland Division of Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany. |
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