Document Detail

Local generation of sulfidopeptide leukotrienes upon nasal provocation with cold, dry air.
MedLine Citation:
PMID:  3013056     Owner:  NLM     Status:  MEDLINE    
In order to assess whether sulfidopeptide leukotrienes are generated following nonimmunologic stimulation of inflammatory cells in vivo, 11 subjects complaining of symptoms of rhinitis when exposed to cold and dry environments were challenged by nasal breathing, first with warm, moist air and then with cold, dry air. Nasal lavages with normal saline were performed before and after each exposure. Immunoreactive leukotriene in the lavage fluids was significantly increased following cold, dry air exposure (2.6 ng/ml) compared with that after warm, moist air exposure (0.7 ng/ml) or at baseline (0.4 ng/ml) (p less than 0.01 in both instances). Six more subjects, denying cold-air sensitivity, were subjected to the same protocol and had no mediator and symptom score changes after cold, dry air challenge. Leukotriene changes after cold, dry air were highly concordant with increments in histamine, prostaglandin D2,N-alpha-tosyl-L-arginine methyl ester (TAME) esterase(s) activity and symptom scores (p less than 0.001). Separation of leukotrienes by high performance liquid chromatography in the nasal washes of 3 subjects showed variable amounts of LTC4, D4, and E4, suggesting metabolism of the former to the latter 2. To our knowledge, this is the first in vivo demonstration of leukotriene production in response to a physical stimulus, and it suggests a possible role of these and other inflammatory mediators in pathologic conditions, such as exercise-induced asthma, that involve physical causative factors.
A G Togias; R M Naclerio; S P Peters; I Nimmagadda; D Proud; A Kagey-Sobotka; N F Adkinson; P S Norman; L M Lichtenstein
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  133     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-07-09     Completed Date:  1986-07-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1133-7     Citation Subset:  AIM; IM    
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MeSH Terms
Chromatography, High Pressure Liquid
Cold Temperature*
Leukotriene E4
Nose / metabolism,  physiology*
Physical Stimulation
SRS-A / analogs & derivatives,  biosynthesis,  metabolism
Grant Support
Reg. No./Substance:
0/SRS-A; 75715-89-8/Leukotriene E4

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