Document Detail


Local flicker stimulation evokes local retinal blood velocity changes.
MedLine Citation:
PMID:  22661609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the effect of localized visual stimulation on human retinal blood velocity using an adaptive optics scanning laser ophthalmoscope (AOSLO). To measure the blood velocity response, the AOSLO scanning raster was moved over the target arteries and red blood cell velocity was measured. Localized visual stimuli were delivered by projecting flicker patterns inside or outside the target artery's downstream region. The blood velocity increased in the presence of a flicker stimulus in the downstream region but not when outside the downstream region. The blood velocity increased more with larger area of stimulation. This increase was significant even when the stimulus was smaller than 600 μm × 600 μm. These findings suggest that when the retina regulates its blood flow to metabolic demands, it regulates blood velocity in the vascular system selectively, according to activity of neurons within its field of influence.
Authors:
Zhangyi Zhong; Gang Huang; Toco Yuen Ping Chui; Benno L Petrig; Stephen A Burns
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-06-01
Journal Detail:
Title:  Journal of vision     Volume:  12     ISSN:  1534-7362     ISO Abbreviation:  J Vis     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-04     Completed Date:  2012-10-02     Revised Date:  2013-07-08    
Medline Journal Info:
Nlm Unique ID:  101147197     Medline TA:  J Vis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3     Citation Subset:  IM    
Affiliation:
School of Optometry, Indiana University, Bloomington, IN, USA. zhazhong@indiana.edu
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MeSH Terms
Descriptor/Qualifier:
Blood Flow Velocity / physiology*
Humans
Ophthalmoscopy / methods
Photic Stimulation / methods*
Regional Blood Flow / physiology*
Retina / physiology*
Retinal Artery / physiology*
Retinal Ganglion Cells / physiology
Grant Support
ID/Acronym/Agency:
P30 EY019008/EY/NEI NIH HHS; P30EY019008/EY/NEI NIH HHS; R01 EY004395/EY/NEI NIH HHS; R01 EY014375/EY/NEI NIH HHS; R01EY04395/EY/NEI NIH HHS; R01EY14375/EY/NEI NIH HHS
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