| Local expression of antiinflammatory cytokines in cancer. | |
| | |
MedLine Citation:
|
PMID: 8450029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To characterize the nature of the local cytokine response to cancer, we chose to investigate cytokine patterns in biopsy specimens of basal cell carcinoma (BCC). We hypothesized that a distinct pattern of local cytokine production may be characteristic of BCC, a neoplasia of epidermis, in comparison to the pattern of seborrheic keratosis (SK), a benign growth of epidermis. We analyzed cytokine mRNAs in BCC versus SK by performing polymerase chain reaction on mRNA derived from biopsy specimens. The mRNAs encoding cytokines for IL-4, IL-5, IL-10, and granulocyte macrophage colony-stimulating factor were strongly expressed in BCC lesions and weakly expressed in SK lesions. Conversely, IL-2, IFN-gamma, and lymphotoxin mRNAs were strongly expressed in SK lesions and weakly expressed in BCC lesions. The response to malignancy, BCC, was typified by cytokines characteristic of murine TH2 cells. This cytokine pattern favors humoral immunity with concomitant immunosuppression of cell-mediated immune responses. In comparison, the response to the benign growth, SK, was typified by cytokines characteristic of murine TH1 cells that favor cell-mediated immune reactions. The findings of a distinct cytokine pattern in skin cancer provide a framework to develop strategies for immunologic intervention. |
| | |
Authors:
|
M Yamamura; R L Modlin; J D Ohmen; R L Moy |
Related Documents
:
|
11104329 - Heart failure is a fever: the cytokine connection. 15270859 - Rapid simultaneous measurement of multiple cytokines using 100 microl sample volumes--a... 20410069 - Cytokines in sjogren's syndrome: potential therapeutic targets. 12849709 - Expression of cytokines by multipotent neural progenitor cells. 15134469 - Therapeutic potential of anticytokine therapy in congestive heart failure. 16529939 - Cytokine pharmacogenetics. 19410639 - Pro-apoptotic effects of nivalenol and deoxynivalenol trichothecenes in j774a.1 murine ... 8595919 - Pulmonary immunity to pseudomonas aeruginosa. 11994139 - Induction of skewed th1/th2 t-cell differentiation via subcutaneous immunization with f... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of clinical investigation Volume: 91 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 1993 Mar |
Date Detail:
|
Created Date: 1993-04-13 Completed Date: 1993-04-13 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1005-10 Citation Subset: AIM; IM |
Affiliation:
|
Division of Dermatology, University of California, Los Angeles School of Medicine 90024. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anti-Inflammatory Agents* Biopsy Carcinoma, Basal Cell / genetics, immunology*, pathology, surgery Cytokines / biosynthesis*, genetics Humans Interleukins / biosynthesis, genetics Keratosis, Seborrheic / immunology, pathology, surgery Polymerase Chain Reaction / methods RNA, Messenger / analysis, genetics, isolation & purification, metabolism RNA, Neoplasm / genetics, isolation & purification Skin Neoplasms / genetics, immunology*, pathology, surgery |
| Grant Support | |
ID/Acronym/Agency:
|
AI 22553/AI/NIAID NIH HHS; AI 28508/AI/NIAID NIH HHS; AR 40312/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Inflammatory Agents; 0/Cytokines; 0/Interleukins; 0/RNA, Messenger; 0/RNA, Neoplasm |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Analysis of lysosomal degradation of fluorescein isothiocyanate- labelled proteins by Toyopearl HW-4...
Next Document: Lipoprotein-proteoglycan complexes induce continued cholesteryl ester accumulation in foam cells fro...