Document Detail

Local expression of antiinflammatory cytokines in cancer.
MedLine Citation:
PMID:  8450029     Owner:  NLM     Status:  MEDLINE    
To characterize the nature of the local cytokine response to cancer, we chose to investigate cytokine patterns in biopsy specimens of basal cell carcinoma (BCC). We hypothesized that a distinct pattern of local cytokine production may be characteristic of BCC, a neoplasia of epidermis, in comparison to the pattern of seborrheic keratosis (SK), a benign growth of epidermis. We analyzed cytokine mRNAs in BCC versus SK by performing polymerase chain reaction on mRNA derived from biopsy specimens. The mRNAs encoding cytokines for IL-4, IL-5, IL-10, and granulocyte macrophage colony-stimulating factor were strongly expressed in BCC lesions and weakly expressed in SK lesions. Conversely, IL-2, IFN-gamma, and lymphotoxin mRNAs were strongly expressed in SK lesions and weakly expressed in BCC lesions. The response to malignancy, BCC, was typified by cytokines characteristic of murine TH2 cells. This cytokine pattern favors humoral immunity with concomitant immunosuppression of cell-mediated immune responses. In comparison, the response to the benign growth, SK, was typified by cytokines characteristic of murine TH1 cells that favor cell-mediated immune reactions. The findings of a distinct cytokine pattern in skin cancer provide a framework to develop strategies for immunologic intervention.
M Yamamura; R L Modlin; J D Ohmen; R L Moy
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  91     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-04-13     Completed Date:  1993-04-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1005-10     Citation Subset:  AIM; IM    
Division of Dermatology, University of California, Los Angeles School of Medicine 90024.
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MeSH Terms
Anti-Inflammatory Agents*
Carcinoma, Basal Cell / genetics,  immunology*,  pathology,  surgery
Cytokines / biosynthesis*,  genetics
Interleukins / biosynthesis,  genetics
Keratosis, Seborrheic / immunology,  pathology,  surgery
Polymerase Chain Reaction / methods
RNA, Messenger / analysis,  genetics,  isolation & purification,  metabolism
RNA, Neoplasm / genetics,  isolation & purification
Skin Neoplasms / genetics,  immunology*,  pathology,  surgery
Grant Support
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Cytokines; 0/Interleukins; 0/RNA, Messenger; 0/RNA, Neoplasm

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