Document Detail

Local effects of high-powered neodymium-doped yttrium aluminium garnet laser systems on the pulmonary parenchyma: an experimental study on the isolated perfused pig lung lobe.
MedLine Citation:
PMID:  22535543     Owner:  NLM     Status:  MEDLINE    
Neodymium-doped yttrium aluminium garnet (Nd:YAG) laser systems (with a power output up to 100 W, wavelength 1318 nm) have been introduced into clinical practice for resecting lung metastases. However, the extent of the local effect on the lung parenchyma and the role of the application time are unknown. All experiments were performed on normothermal, whole-blood-perfused paracardiac pig lung lobes (n = 6). Lobes were not ventilated during the laser application. The laser itself was clamped into a hydraulic feed system that moves horizontally at two different constant rates (10 and 20 mm/s). A 30-mm focus distance from the pulmonary parenchyma was maintained at all times. At each feed rate, the laser was applied thrice along a horizontal path using laser power outputs of 40, 60 and 100 W. After lasering, we recruited the lungs via a ventilation tube using pressures of up to 40 cm H(2)O and tested lung tightness. Both a gross inspection and a histological examination revealed larger coagulation zones for higher power outputs and lower laser feed rates. Exposure to higher outputs for shorter application times reduced the laser effect. When lungs were manually recruited, all lungs were airtight up to a pressure of 40 mmHg. Reducing the exposure time reduces local tissue coagulation even when the laser power output is increased.
Andreas Kirschbaum; Emanuel Palade; Gian Kayser; Bernward Passlick
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Publication Detail:
Type:  Journal Article     Date:  2012-04-25
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  15     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-17     Completed Date:  2012-11-19     Revised Date:  2013-08-14    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  191-3     Citation Subset:  IM    
Department of Thoracic Surgery, University Hospital Freiburg, Freiburg, Germany.
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MeSH Terms
Equipment Design
Laser Therapy / adverse effects,  instrumentation*
Lasers, Solid-State* / adverse effects
Lung / blood supply*,  pathology,  surgery*
Surgery, Computer-Assisted / adverse effects,  instrumentation*
Time Factors

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