Document Detail


Local effects of TL01 phototherapy in psoriasis.
MedLine Citation:
PMID:  18811869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanisms whereby narrowband ultraviolet B (UVB) (311-313 nm, TL01) phototherapy are effective in psoriasis may differ from those occurring in broadband UVB phototherapy. In the present study, changes in epidermal cells as a result of TL01 therapy were assessed in the skin of patients with psoriasis. The non-lesional skin of five subjects with plaque psoriasis was biopsied before and after a series of 12 whole-body TL01 treatments. Following appropriate staining of skin sections, the numbers of p53-positive keratinocytes, sunburn cells and Langerhans cells in the epidermis were counted. TL01 therapy induced a threefold increase in the number of p53-positive epidermal cells, a 12-fold increase in sunburn cells and a twofold decrease in Langerhans cells. The increase in epidermal p53 expression and apoptosis of keratinocytes together with the depletion of Langerhans cells in the non-lesional skin of psoriasis patients are likely to contribute to the effectiveness of TL01 phototherapy.
Authors:
Bernadette DeSilva; Roddie C McKenzie; John A A Hunter; Mary Norval
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Photodermatology, photoimmunology & photomedicine     Volume:  24     ISSN:  1600-0781     ISO Abbreviation:  Photodermatol Photoimmunol Photomed     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-24     Completed Date:  2008-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013641     Medline TA:  Photodermatol Photoimmunol Photomed     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  268-9     Citation Subset:  IM    
Affiliation:
Department of Dermatology, University of Edinburgh, Edinburgh, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Apoptosis / radiation effects*
Cell Count
Female
Humans
Keratinocytes / metabolism*,  pathology
Langerhans Cells / metabolism,  pathology
Male
Middle Aged
Psoriasis / metabolism*,  pathology,  therapy*
Skin / metabolism*,  pathology
Tumor Suppressor Protein p53 / metabolism
Ultraviolet Therapy* / methods
Chemical
Reg. No./Substance:
0/TP53 protein, human; 0/Tumor Suppressor Protein p53

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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