Document Detail

Local dental anaesthesia with lidocaine and adrenaline. Effects on plasma catecholamines, heart rate and blood pressure.
MedLine Citation:
PMID:  3145958     Owner:  NLM     Status:  MEDLINE    
5 volunteers took part in this double-blind, cross-over study to evaluate the role of adrenaline 1:80,000 in lidocaine used in dental local anaesthesia on haemodynamics and the concentrations of catecholamines and their metabolites in plasma. The exogenous adrenaline statistically significantly elevated the heart rate (from 66 +/- 7 to 79 +/- 9 bpm), but did not affect systolic or diastolic blood pressure. Plasma adrenaline concentrations were increased more than 10-fold (from 0.02 +/- 0.02 to 1.0 +/- 0.3 nmol/l). We conclude that the adrenaline present in the local anaesthetic is a major source of adrenergic activation during minor oral surgery.
M Salonen; H Forssell; M Scheinin
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of oral and maxillofacial surgery     Volume:  17     ISSN:  0901-5027     ISO Abbreviation:  Int J Oral Maxillofac Surg     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-03-02     Completed Date:  1989-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8605826     Medline TA:  Int J Oral Maxillofac Surg     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  392-4     Citation Subset:  D; IM    
Department of Anasthesiology, University of Turku, Finland.
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MeSH Terms
Anesthesia, Dental*
Anesthesia, Local*
Blood Pressure / drug effects*
Catecholamines / blood*
Double-Blind Method
Epinephrine / pharmacology*
Heart Rate / drug effects*
Lidocaine / pharmacology*
Random Allocation
Reg. No./Substance:
0/Catecholamines; 137-58-6/Lidocaine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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