| Local dental anaesthesia with lidocaine and adrenaline. Effects on plasma catecholamines, heart rate and blood pressure. | |
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MedLine Citation:
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PMID: 3145958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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5 volunteers took part in this double-blind, cross-over study to evaluate the role of adrenaline 1:80,000 in lidocaine used in dental local anaesthesia on haemodynamics and the concentrations of catecholamines and their metabolites in plasma. The exogenous adrenaline statistically significantly elevated the heart rate (from 66 +/- 7 to 79 +/- 9 bpm), but did not affect systolic or diastolic blood pressure. Plasma adrenaline concentrations were increased more than 10-fold (from 0.02 +/- 0.02 to 1.0 +/- 0.3 nmol/l). We conclude that the adrenaline present in the local anaesthetic is a major source of adrenergic activation during minor oral surgery. |
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Authors:
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M Salonen; H Forssell; M Scheinin |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of oral and maxillofacial surgery Volume: 17 ISSN: 0901-5027 ISO Abbreviation: Int J Oral Maxillofac Surg Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1989-03-02 Completed Date: 1989-03-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8605826 Medline TA: Int J Oral Maxillofac Surg Country: DENMARK |
Other Details:
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Languages: eng Pagination: 392-4 Citation Subset: D; IM |
Affiliation:
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Department of Anasthesiology, University of Turku, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthesia, Dental* Anesthesia, Local* Blood Pressure / drug effects* Catecholamines / blood* Double-Blind Method Epinephrine / pharmacology* Female Heart Rate / drug effects* Humans Lidocaine / pharmacology* Male Random Allocation |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 137-58-6/Lidocaine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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