| Local delivery of sirolimus nanoparticles for the treatment of in-stent restenosis. | |
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MedLine Citation:
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PMID: 22566402 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: To test the local delivery of sirolimus nanoparticles following percutaneous transluminal coronary angioplasty (PTCA) to treat in-stent restenosis (ISR) in a swine model. BACKGROUND: Coronary bare-metal stent (BMS) implantation reduces major adverse cardiac events when compared with PTCA; however, ISR rates remain high. METHODS: Eighteen swine underwent BMS deployment guided by intravascular ultrasound (IVUS). Of these, 16 developed ISR (1 stent/swine) and underwent angioplasty with a noncompliant balloon (PTCA-NC). The animals were then randomized into four groups for local infusion of sirolimus nanoparticles through a porous balloon catheter, as follows: (1) PTCA-NC alone (control); (2) PTCA-NC + (polylactic acid)-based nanoparticle formulation (anionic 1); (3) PTCA-NC + (polylactic-co-glycolic acid)-based nanoparticle formulation (anionic 2); and (4) PTCA-NC + Eudragit RS nanoparticle formulation (cationic). Coronary angiography and IVUS follow-up were performed 28 days after ISR treatment. RESULTS: There was one episode of acute coronary occlusion with the cationic formulation. Late area loss was similar in all groups at 28 days according to IVUS. However, luminal volume loss (control = 20.7%, anionic 1 = 4.0%, anionic 2 = 6.7%, cationic = 9.6%; P = 0.01) and neointimal volume gain (control = 68.7%, anionic 1 = 17.4%, anionic 2 = 29.5%, cationic = 31.2%; P = 0.019) were significantly reduced in all treatment groups, especially in anionic 1. CONCLUSIONS: PTCA-NC followed by local infusion of sirolimus nanoparticles was safe and efficacious to reduce neointima in this model, and this strategy may be a promising treatment for BMS ISR. Further studies are required to validate this method in humans. © 2012 Wiley Periodicals, Inc. |
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Authors:
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Alexandre C Zago; José C Raudales; Guilherme Attizzani; Bruno S Matte; German I Yamamoto; Julise A Balvedi; Ludmila Nascimento; Beatriz G Kosachenco; Paulo R Centeno; Alcides J Zago |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-4 |
Journal Detail:
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Title: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Volume: - ISSN: 1522-726X ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100884139 Medline TA: Catheter Cardiovasc Interv Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Cardiovascular Research Center, Universidade Luterana do Brasil (ULBRA), Canoas, Rio Grande do Sul, Brazil. zagoac@uol.com.br. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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