| Local delivery of chlorhexidine gluconate in patients with aggressive periodontitis. | |
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MedLine Citation:
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PMID: 18333598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this randomized, controlled, single-blinded trial was to evaluate the effectiveness of a biodegradable chlorhexidine chip as an adjunctive therapy to scaling and root planing. Eleven consecutive patients with aggressive periodontitis were recruited for this study. Each volunteer provided four sites with probing depth > or = 5 mm. Two sites received scaling and root planing (SRP) and placement of the chlorhexidine chip (PC), and the other two sites received scaling and root planing only. The clinical outcomes were measured at baseline, 6 weeks and 3 months after treatment. All patients completed the trial. None of the volunteers reported any adverse effect. Both groups showed a significant reduction in periodontal pocket depth (PPD) and gain in clinical attachment level (CAL) after treatment. However, there were no significant differences in the clinical parameters between the groups after 6 weeks and after 3 months. Sites presenting probing depths > or = 8 mm at baseline treated with SRP + PC demonstrated greater reduction in PPD and a greater CAL gain than sites treated with SRP alone after 6 weeks and after 3 months. The authors concluded that the adjunctive use of the biodegradable chlorhexidine chip resulted in greater reduction of PPD and additional gain in CAL in deep pockets (PPD > or = 8 mm) in patients with aggressive periodontitis when compared to scaling and root. |
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Authors:
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Fabio de Freitas Duarte; Roberto Fraga Moreira Lotufo; Cláudio Mendes Pannuti |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of the International Academy of Periodontology Volume: 10 ISSN: 1466-2094 ISO Abbreviation: J Int Acad Periodontol Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-03-12 Completed Date: 2008-04-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888553 Medline TA: J Int Acad Periodontol Country: England |
Other Details:
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Languages: eng Pagination: 31-5 Citation Subset: D |
Affiliation:
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Department of Periodontology, School of Dentistry, University of São Paulo, São Paulo, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Anti-Infective Agents, Local / therapeutic use* Chlorhexidine / analogs & derivatives*, therapeutic use Delayed-Action Preparations Dental Scaling Female Humans Male Periodontitis / drug therapy* Single-Blind Method Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Local; 0/Delayed-Action Preparations; 18472-51-0/chlorhexidine gluconate; 55-56-1/Chlorhexidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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