Document Detail


Local degradation of luteinizing hormone-releasing hormone (LH-RH) in the rat central nervous system.
MedLine Citation:
PMID:  19605087     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Peptidases inactivating luteinizing hormone-releasing hormone (LH-RH) were found to be present in two subcellular fractions prepared from the following areas of the central nervous system of male and female rats: thalamus, hypothalamus, cortex and cerebellum. LH-RH immunoreactivity was also detected in these fractions after peptidase activity had been removed by heat denaturation. These findings support the concept that LH-RH may have a role in modulating neuronal activity within the central nervous system (CNS).
Authors:
E C Griffiths; R Forbes; S L Jeffcoate; D T Holland
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  7     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1978 Jan 
Date Detail:
Created Date:  2009-07-16     Completed Date:  2009-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  49-53     Citation Subset:  -    
Affiliation:
Department of Physiology, Stopford Building, University of Manchester, Manchester M13 9PT, Great Britain.
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