Document Detail


Local danazol injection for treatment of unruptured tubal pregnancy (preliminary experience).
MedLine Citation:
PMID:  7691665     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fifteen women with unruptured tubal pregnancies diagnosed by laparoscopy and ultrasound were treated with danazol 400 mg, injected directly into the affected tube. Study inclusion criteria were (i) a rising or plateauing level of serum beta human chorionic gonadotropin (hCG), (ii) a tubal swelling less than 3 x 3 cm, (iii) an intact tubal serosa and (iv) no active bleeding. The women were monitored with serial measurements of beta-hCG. All women responded to a single danazol injection, no treatment failures were observed. After 3 months, hysterosalpinography revealed tubal pateny on the involved side in 14 patients and in 1 patient the tube was blocked. Within 1 year after danazol therapy patients were attempting to or had conceived. Of these, there were 3 intrauterine pregnancies and 2 recurrent contralateral pregnancies.
Authors:
A F Ali
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  49     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-10-25     Completed Date:  1993-10-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  137-41     Citation Subset:  IM    
Affiliation:
Department of Gynaecology and Obstetrics, Faculty of Medicine, Ain Shams University, Heliopolis, Cairo, Egypt.
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MeSH Terms
Descriptor/Qualifier:
Chorionic Gonadotropin / blood
Chorionic Gonadotropin, beta Subunit, Human
Danazol / administration & dosage*
Fallopian Tubes
Female
Follow-Up Studies
Humans
Injections
Laparoscopy
Peptide Fragments / blood
Pregnancy
Pregnancy, Tubal / drug therapy*
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Peptide Fragments; 17230-88-5/Danazol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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