| Local cerebral glucose utilization decreases after heatstroke onset in rats. | |
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MedLine Citation:
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PMID: 11479024 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The quantitative autoradiographic 2-[(14)C]-deoxy-D-glucose methods were used to assess the local cerebral glucose utilization (LCGU) in 46 brain structures in rats suffering from heatstroke. Heatstroke was induced by exposing the animals to an ambient temperature of 42 degrees C. The time at which the local cerebral blood flow (CBF) and mean arterial pressure (MAP) decreased from their peak levels was taken as the onset of heatstroke. Control rats were exposed to a temperature of 24 degrees C. The values of local CBF, MAP and means of total LCGU after heatstroke onset were all significantly lower than those in control rats. However, the values of colonic temperature were greater. Thus, it appears that the decreased cerebral metabolism and perfusion can be due to secondary effect of hypertension after heatstroke onset. |
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Authors:
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L Chang; Y Huang; M Lin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 308 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-07-31 Completed Date: 2001-09-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 206-8 Citation Subset: IM |
Affiliation:
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Institute of Physiology, National Yang-Ming University, Taipei, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Radioisotopes / diagnostic use Cerebral Cortex / blood supply, metabolism* Cerebrovascular Circulation Deoxyglucose / pharmacokinetics Glucose / metabolism* Heat Stroke / metabolism* Hypotension / metabolism Male Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 154-17-6/Deoxyglucose; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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