Document Detail


Local cerebral blood flow and glucose metabolism in hydrostatic brain edema.
MedLine Citation:
PMID:  7683119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigated the effect of hydrostatic pressure gradient on the cerebrovascular dynamics and metabolism during the development of brain edema. Hydrostatic brain edema was induced by bolus injection of autologous blood through the common carotid artery in Sprague-Dawley rats. Rats were divided into two groups, with craniectomy (Cr+ group) and without (Cr- group). Animals were sacrificed 0, 24, and 48 hours after hypertensive insult. Brain water content was determined by the gravimetric method. Regional cerebral blood flow and local cerebral glucose utilization were measured by the quantitative autoradiographic method using [14C]iodoantipyrine and [14C]deoxyglucose, respectively. Hypertensive insult produced multifocal lesions stained by Evans blue. Brains from the Cr- group showed a transient increase in water content and no significant change in cerebrovascular dynamics and metabolism. Brains from the Cr+ group showed a pronounced increase in water content which persisted 48 hours later. Misery perfusion was also observed 24 hours after the insult and the cerebrovascular dynamics and metabolism were significantly decreased after 48 hours. These results indicate that an increased hydrostatic pressure gradient enhances tissue damage and causes reopening of the blood-brain barrier.
Authors:
H Umezawa; K Shima; H Chigasaki; S Ishii
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurologia medico-chirurgica     Volume:  33     ISSN:  0470-8105     ISO Abbreviation:  Neurol. Med. Chir. (Tokyo)     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-05-26     Completed Date:  1993-05-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0400775     Medline TA:  Neurol Med Chir (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  139-45     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, National Defense Medical College, Saitama.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / metabolism*
Blood Pressure / physiology*
Brain / blood supply*,  pathology
Brain Edema / pathology,  physiopathology*,  surgery
Craniotomy
Intracranial Pressure / physiology*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Blood Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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