Document Detail


Local calcitriol injections as a suppressive treatment of secondary hyperparathyroidism in chronic dialysis patients.
MedLine Citation:
PMID:  18067038     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: A prospective study was made of the effectiveness of repeatable local calcitriol injections therapy to suppress secondary hyperparathyroidism resistant to conventional therapy in chronic dialysis patients. METHODS: Under ultrasonographic guidance, six injections at an interval of two days were performed in 14 chronic dialysis patients. The total amount of calcitriol to be injected each time was estimated as 100% of the calculated gland volume. Calcitriol was given in doses 1 mug of medicine per 1 cubic cm (as measured by USG) of parathyroid tissue. Parathormone concentration, total calcium, ionized calcium, phosphate, and alkaline phosphatase levels were assessed on the first and last day of the treatment period. RESULTS: Prior to therapy, the mean gland volumes were 0.62 (0.15-3.0) ml, and they increased to 0.85 (0.2-3.9) after 14 days (NS). Seven patients were found to have decreased their PTH levels to 909 +/- 387 pg/mL after 14 days of treatment when compared with the first day mean values of 1588 +/- 440 pg/mL (p < 0.05). After completion of the therapy, four patients were reported to be free from any clinical symptoms of ostalgia or arthralgia. Others reported an alleviation of pain. CONCLUSIONS: Parathyroid adenoma injection is an alternative method of treatment for some patients resistant to treatment by means of vitamin D3 pulses or intravenous administration of calcitriol. The success of treatment is to a great extent determined by proper selection of patients and the taking of decisions when the period of secondary hyperparathyroidism is not very advanced.
Authors:
Roman Junik; Magdalena Polaáska; Jacek Manitius; Witold Doroszewski; Grazyna Sypniewska; Marzenna Gruszka
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  29     ISSN:  0886-022X     ISO Abbreviation:  Ren Fail     Publication Date:  2007  
Date Detail:
Created Date:  2007-12-10     Completed Date:  2008-03-07     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  941-5     Citation Subset:  IM    
Affiliation:
Department of Endocrinology and Diabetology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland. junik@cm.umk.pl
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Calcitriol / administration & dosage*
Female
Humans
Hyperparathyroidism, Secondary / drug therapy*
Injections
Male
Middle Aged
Prospective Studies
Renal Dialysis / adverse effects*
Vitamins / administration & dosage*
Chemical
Reg. No./Substance:
0/Vitamins; 32222-06-3/Calcitriol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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