Document Detail


Local bisphosphonate release versus hydroxyapatite coating for stainless steel screw fixation in rat tibiae.
MedLine Citation:
PMID:  22203517     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Implant fixation in bone can be improved by a coating that delivers bisphosphonates locally, or by a hydroxyapatite (HA) coating. In this study, we compared these different types of coatings. For mechanical testing, 30 rats were assigned into three groups, and similar screws were implanted bilaterally in the proximal tibiae. The rats received screws that were either uncoated, coated with nano-crystalline hydroxyapatite or coated with a bisphosphonate releasing protein matrix. After 4 weeks, one screw was subjected to pull-out testing, and the contra-lateral one to torsion testing. For morphology, 30 rats were assigned to similar treatment groups, but received only one screw each. Bisphosphonates enhanced the pull-out force by 41% (P = 0.02) compared to controls, HA increased the pull-out force although not significantly. Conversely, HA increased the maximal torque by 64% (P = 0.02). Morphometry showed higher bone volume around bisphosphonate screws in comparison to HA-coated screws (P < 0.001) and controls (P < 0.001). The results suggest that bisphosphonates improve fixation by increasing the amount of surrounding bone, whereas HA mainly improves bone to implant attachment.
Authors:
F Agholme; T Andersson; P Tengvall; P Aspenberg
Related Documents :
10403457 - Dental composite resins containing silica-fused ceramic single-crystalline whiskers wit...
1847237 - Enhanced osseointegration of hydroxylapatite implant material.
10149977 - Biodegradable self-reinforced composite materials; manufacturing structure and mechanic...
18260547 - Effect of woven glass fibre reinforcement on the flexural strength of composites.
22394057 - A semi-autonomous model of endochondral ossification for developmental tissue engineering.
8940537 - Contact angle of dentin bonding agents on the dentin surface.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-28
Journal Detail:
Title:  Journal of materials science. Materials in medicine     Volume:  -     ISSN:  1573-4838     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013087     Medline TA:  J Mater Sci Mater Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Orthopedics, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linköping University, 58185, Linköping, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Programmed water-induced shape-memory of bioabsorbable poly(D: ,L: -lactide): activation and propert...
Next Document:  Ecological Momentary Assessment of the Relationship between Intention and Physical Activity Behavior...