Document Detail

Local application of zoledronate for maximum anchorage during space closure.
MedLine Citation:
PMID:  23195364     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: Orthodontists have used various compliance-dependent physical means such as headgears and intraoral appliances to prevent anchorage loss. The aim of this study was to determine whether 1 local application of the bisphosphonate zoledronate could be used to prevent anchorage loss during extraction space closure in rats.
METHODS: Thirty rats had their maxillary left first molars extracted and their maxillary left second molars protracted into the extraction space with a 10-g nickel-titanium closing coil for 21 days. Fifteen control rats received a local injection of phosphate-buffered saline solution, and 15 experimental rats received 16 μg of the bisphosphonate zoledronate. Bisphosphonate was also delivered directly into the extraction site and left undisturbed for 5 minutes. Cephalograms and incremental thickness gauges were used to measure tooth movements. Tissues were analyzed by microcomputed tomography and histology.
RESULTS: The control group demonstrated significant (P <0.05) tooth movements throughout the 21-day period. They showed significantly greater tooth movements than the experimental group beginning in the second week. The experimental group showed no significant tooth movement after the first week. The microcomputed tomography and histologic observations showed significant bone loss in the extraction sites and around the second molars of the controls. In contrast, the experimental group had bone preservation and bone fill. There was no evidence of bisphosphonate-associated osteonecrosis in any sample.
CONCLUSIONS: A single small, locally applied dose of zoledronate provided maximum anchorage and prevented significant bone loss.
Adam J Aj Ortega; Phillip M Campbell; Robert Hinton; Aparna Naidu; Peter H Buschang
Related Documents :
19567204 - Expression of il-10 and tnf-alpha in rats with cerebral infarction after transplantatio...
10467254 - Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damag...
16464234 - Aminoguanidine inhibits caspase-3 and calpain activation without affecting microglial a...
19628804 - Minocycline and tissue-type plasminogen activator for stroke: assessment of interaction...
1526954 - Adaptations of young adult rat cortical bone to 14 days of spaceflight.
6547364 - Ontogeny of a novel peptide, neuropeptide y (npy) in rat brain.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics     Volume:  142     ISSN:  1097-6752     ISO Abbreviation:  Am J Orthod Dentofacial Orthop     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610224     Medline TA:  Am J Orthod Dentofacial Orthop     Country:  United States    
Other Details:
Languages:  eng     Pagination:  780-91     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2012 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.
Private practice, Dallas, Tex.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Skeletal maturation in obese patients.
Next Document:  Long-term stability of anterior open-bite closure with bilateral sagittal split osteotomy.