Document Detail

Local anesthetics. Is there an advantage to mixing solutions?
MedLine Citation:
PMID:  8918026     Owner:  NLM     Status:  MEDLINE    
The advantages to using a 50/50 mixture of lidocaine and bupivacaine with respect to onset and duration of local anesthesia instead of using the solutions independently were evaluated. In a double-blind randomized experiment, 12 subjects, each volunteering both feet, were studied. One foot was injected with 1 ml of one of the following three solutions: 1% plain lidocaine, 0.25% plain bupivacaine (Marcaine), or a 50/50 mixture of 1% lidocaine and 0.25% bupivacaine; and in the other foot, a 1-ml injection of normal saline as a blinded control. A 5.07 (10 g) Semmes-Weinstein monofilament wire was used for testing for sensory blockade, and the onset and duration of anesthesia was recorded for each subject. It was determined that there was no significant difference in the mean onset times for the three solutions, and no significant difference between the durations of anesthesia of plain lidocaine and the 50/50 mixture. Additionally, it was determined that bupivacaine had a prolonged duration of anesthesia compared with the other two solutions. The results of this preliminary study suggest that there is no clinical advantage, with respect to onset and duration of local blockade, to using a 50/50 mixture of plain lidocaine and plain bupivacaine in place of their independent use.
B M Ribotsky; K D Berkowitz; J R Montague
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the American Podiatric Medical Association     Volume:  86     ISSN:  8750-7315     ISO Abbreviation:  J Am Podiatr Med Assoc     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-12-27     Completed Date:  1996-12-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8501423     Medline TA:  J Am Podiatr Med Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  487-91     Citation Subset:  IM    
American Board of Podiatric Surgery, Boca Raton, FL 33486, USA.
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MeSH Terms
Analysis of Variance
Anesthesia, Local
Anesthetics, Local / administration & dosage,  therapeutic use*
Bupivacaine / administration & dosage*,  therapeutic use
Double-Blind Method
Drug Therapy, Combination
Lidocaine / administration & dosage*,  therapeutic use
Reference Values
Sensation / drug effects
Reg. No./Substance:
0/Anesthetics, Local; 137-58-6/Lidocaine; 2180-92-9/Bupivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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