Document Detail

Local anesthetics and their adjuncts.
MedLine Citation:
PMID:  21923815     Owner:  NLM     Status:  MEDLINE    
Local anesthetics (LA) block propagation of impulses along nerve fibers by inactivation of voltage-gated sodium channels, which initiate action potentials (1). They act on the cytosolic side of phospholipid membranes. Two main chemical compounds are used, amino esters and amino amides. Amino esters are degraded by pseudocholinesterases in plasma. Amino amides are metabolized exclusively by the liver. Only amide LAs will be considered in this article.
Jean-Xavier Mazoit
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-09-16
Journal Detail:
Title:  Paediatric anaesthesia     Volume:  22     ISSN:  1460-9592     ISO Abbreviation:  Paediatr Anaesth     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-01     Completed Date:  2012-04-05     Revised Date:  2012-07-03    
Medline Journal Info:
Nlm Unique ID:  9206575     Medline TA:  Paediatr Anaesth     Country:  France    
Other Details:
Languages:  eng     Pagination:  31-8     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Département d'Anesthésie-Réanimation, Hôpitaux Universitaires Paris-Sud, AP-HP, Le Kremlin-Bicětre, France.
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MeSH Terms
Adjuvants, Anesthesia
Anesthetics, Local / blood,  chemistry,  pharmacokinetics,  pharmacology*
Cardiovascular System / drug effects
Central Nervous System / drug effects
Nerve Fibers / drug effects
Tissue Distribution
Reg. No./Substance:
0/Adjuvants, Anesthesia; 0/Anesthetics, Local
Comment In:
Paediatr Anaesth. 2012 Jun;22(6):581; author reply 581   [PMID:  22594410 ]

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