| Local anesthetics and their adjuncts. | |
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MedLine Citation:
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PMID: 21923815 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Local anesthetics (LA) block propagation of impulses along nerve fibers by inactivation of voltage-gated sodium channels, which initiate action potentials (1). They act on the cytosolic side of phospholipid membranes. Two main chemical compounds are used, amino esters and amino amides. Amino esters are degraded by pseudocholinesterases in plasma. Amino amides are metabolized exclusively by the liver. Only amide LAs will be considered in this article. |
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Authors:
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Jean-Xavier Mazoit |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-16 |
Journal Detail:
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Title: Paediatric anaesthesia Volume: - ISSN: 1460-9592 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9206575 Medline TA: Paediatr Anaesth Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Département d'Anesthésie-Réanimation, Hôpitaux Universitaires Paris-Sud, AP-HP, Le Kremlin-Bicětre, France Laboratoire d'anesthésie INSERM UMR 788, Université Paris Sud, Le Kremlin-Bicêtre, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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