| Local anesthetic systemic toxicity: a historical perspective. | |
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MedLine Citation:
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PMID: 20216034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The most feared complication associated with the administration of local anesthetics is the profound and potentially lethal effect that these agents can have on cardiac conduction and function. This review traces the evolution of local anesthetic systemic toxicity beginning with the early deaths associated with the introduction of cocaine into clinical practice. The development of bupivacaine is discussed, with particular emphasis on the delayed recognition and acceptance of its inherent cardiotoxicity. Finally, the origins of lipid resuscitation are reviewed with respect to their theoretical foundation, as well as the confluence of events and experimental investigations that delivered this therapy into clinical practice. |
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Authors:
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Kenneth Drasner |
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Publication Detail:
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Type: Historical Article; Journal Article |
Journal Detail:
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Title: Regional anesthesia and pain medicine Volume: 35 ISSN: 1532-8651 ISO Abbreviation: Reg Anesth Pain Med Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-03-10 Completed Date: 2011-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9804508 Medline TA: Reg Anesth Pain Med Country: United States |
Other Details:
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Languages: eng Pagination: 162-6 Citation Subset: IM |
Affiliation:
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University of California, San Francisco, CA 94110, USA. kdrasner@anesthesia.ucsf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Local
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history,
poisoning* Animals Bupivacaine / poisoning Cocaine / history, poisoning Heart / drug effects* History, 19th Century History, 20th Century Humans Lipids / therapeutic use* Procaine / history, poisoning |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Lipids; 2180-92-9/Bupivacaine; 50-36-2/Cocaine; 59-46-1/Procaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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