Document Detail

Local amygdala structural differences with 3T MRI in patients with Alzheimer disease.
MedLine Citation:
PMID:  21339500     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Histologic studies show that the amygdala is affected by Alzheimer disease (AD) pathology, and its medial aspect is the most involved. We aimed to assess in vivo local structural differences in the amygdala of patients with AD using high-field MRI.
METHODS: A total of 19 patients with AD (mean age 76, SD 6 years, mean Mini-Mental State Examination score [MMSE] 13, SD 4) and 19 healthy elderly controls (age 74, SD 5, MMSE 29, SD 1) were enrolled. The radial atrophy mapping technique was used to reconstruct the 3-dimensional surface of the amygdala. Maps of surface tissue loss in patients with AD vs controls were computed and statistically tested with permutation tests thresholded at p < 0.05, to correct for multiple comparisons. A digital atlas of the amygdalar nuclei was used to infer which nuclei were involved.
RESULTS: Both amygdalar volumes were significantly smaller in patients with AD (right 1,508 mm³, SD 418; left 1,646, SD 419) than controls (right 2,129 mm³, SD 316; left 2,077, SD 376; p < 0.002). In the dorsomedial part, significant local tissue loss (20%-30%) was mapped in the medial and central nuclei. Ventrally, the lateral nucleus (La) and the basolateral ventral medial nucleus (BLVM) were also involved (20%-30% loss).
CONCLUSIONS: We found in vivo local structural differences in the amygdala of patients with AD. The nuclei involved have known connections to the hippocampus (BLVM, La) and olfactory system (medial nucleus) and with cholinergic pathways (central nucleus). This pattern is consistent with the known pathophysiology of neural systems affected by AD.
E Cavedo; M Boccardi; R Ganzola; E Canu; A Beltramello; C Caltagirone; P M Thompson; G B Frisoni
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  76     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-22     Completed Date:  2011-04-08     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  727-33     Citation Subset:  AIM; IM    
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / pathology*,  physiopathology
Amygdala / pathology*
Brain Mapping
Imaging, Three-Dimensional*
Magnetic Resonance Imaging*
Mental Status Schedule
Neuropsychological Tests
Grant Support
R01 EB008281/EB/NIBIB NIH HHS; R01 EB008281-13/EB/NIBIB NIH HHS; R01 EB008281-14/EB/NIBIB NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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