| Local adoptive transfer of antitumor cellular immunity to xenogeneic animals studied with a rapid radioisotopic footpad assay. | |
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MedLine Citation:
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PMID: 1003496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antitumor cellular immune response to Gross virus-induced rat tumor cells in F344 rats, as measured by a sensitive radioisotopic footpad assay, was adoptively transferred to syngeneic rats and to xenogeneic irradiated BALB/c mice. Xenogeneic transfer was accomplished by the injection of a mixture of rat tumor cells and syngeneic spleen cells, peritoneal exudate cells, or blood lymphocytes from specific immune rats into the footpads of mice. Peritoneal exudate cells produced the strongest footpad reaction in xenogeneic recipients. Use of the xenogeneic adoptive transfer system in a bioassay for human antitumor immunity appeared feasible. |
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Authors:
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N Takeichi; G C Economou; C W Boone |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the National Cancer Institute Volume: 57 ISSN: 0027-8874 ISO Abbreviation: J. Natl. Cancer Inst. Publication Date: 1976 Jul |
Date Detail:
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Created Date: 1977-02-16 Completed Date: 1977-02-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503089 Medline TA: J Natl Cancer Inst Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 131-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Neoplasm Female Immunity, Cellular* Immunization, Passive* Lymphocytes / immunology Male Mice Mice, Inbred BALB C Mice, Nude Neoplasm Transplantation Neoplasms, Experimental / immunology* Radioimmunoassay Rats Rats, Inbred F344 Skin Tests / methods* Spleen / immunology Transplantation, Heterologous |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Neoplasm |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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