| Local administration of uridine suppresses the cardinal features of asthmatic airway inflammation. | |
| | |
MedLine Citation:
|
PMID: 20455899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The immuno-modulatory properties of nucleotides such as adenosine or inosine, have been described extensively. Recently, the nucleoside uridine and its analogue 4-thiouridine have gained attention for their protective role in acute lung inflammation. OBJECTIVE: In this study, we investigated the influence of uridine on asthmatic airway inflammation. METHODS: We used the classical ovalbumin (OVA)-alum model, as well as a model of house dust mite-(HDM)-induced airway inflammation. The degree of inflammation was determined by bronchoalveolar lavage (BAL), histology, and measurement of bronchial hyperresponsiveness. RESULTS: Intratracheal treatment of OVA-sensitized animals with uridine before allergen challenge resulted in a reduction in total BAL cells and BAL eosinophils. This was accompanied by reduced tissue infiltration and diminished production of T helper type 2-cytokines by mediastinal lymph node cells. Additionally, mice treated with uridine developed less bronchial hyperresponsiveness. Uridine was also effective in reducing airway inflammation in HDM-induced asthma. The protective effects of uridine were independent of myeloid dendritic cell (mDC) function, because in vitro pre-treatment of allergen-pulsed DCs with uridine did not alter the degree of inflammation. However, uridine inhibited the release of pro-inflammatory mediators in vivo and by cultured lung epithelial cells, suggesting an effect on lung structural cells. CONCLUSION: In summary, we were able to show that uridine inhibits the classical features of asthmatic airway inflammation. As uridine supplementation is well tolerated in humans, it might be a new therapeutic approach for the treatment of bronchial asthma. |
| | |
Authors:
|
T Müller; M Grimm; R P de Vieira; S Cicko; T Dürk; S Sorichter; G Zissel; M Idzko |
Related Documents
:
|
18973099 - Intranasal delivery of t-bet modulates the profile of helper t cell immune responses in... 12412839 - Respiratory and immunologic consequences of marijuana smoking. 16143249 - Differential rates of apoptosis in bronchoalveolar lavage and blood of lung transplant ... 15743779 - Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and... 19561109 - Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells ... 1437319 - The impact of respiratory infections on asthma. 15624699 - Fructose-1,6-diphosphate suppresses t-lymphocyte proliferation, promotes apoptosis and ... 19007349 - Maternal transmission of asthma risk. 19557639 - Function of retinoid acid receptor alpha and p21 in all-trans-retinoic acid-induced acu... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Volume: 40 ISSN: 1365-2222 ISO Abbreviation: Clin. Exp. Allergy Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-12 Completed Date: 2011-01-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8906443 Medline TA: Clin Exp Allergy Country: England |
Other Details:
|
Languages: eng Pagination: 1552-60 Citation Subset: IM |
Copyright Information:
|
© 2010 Blackwell Publishing Ltd. |
Affiliation:
|
Department of Pneumology, University Medical Hospital Freiburg, Freiburg, Germany. tobias.mueller@uniklinikfreiburg.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anti-Inflammatory Agents / pharmacology* Asthma / drug therapy*, immunology Bronchoalveolar Lavage Fluid / chemistry, immunology Cell Separation Cytokines / biosynthesis Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Inflammation / drug therapy, immunology Mice Mice, Inbred BALB C Ovalbumin / immunology Pneumonia / drug therapy*, immunology Uridine / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Inflammatory Agents; 0/Cytokines; 58-96-8/Uridine; 9006-59-1/Ovalbumin |
| Comments/Corrections | |
Comment In:
|
Clin Exp Allergy. 2010 Oct;40(10):1436-8
[PMID:
20937059
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Expression of CCR8 is increased in asthma.
Next Document: Impact of cross-reactive carbohydrate determinants on wood dust sensitization.