Document Detail

Local administration of low dose simvastatin-conjugated gelatin hydrogel for tendon-bone healing in anterior cruciate ligament reconstruction.
MedLine Citation:
PMID:  23198912     Owner:  NLM     Status:  Publisher    
Abstract OBJECTIVES: Anterior cruciate ligament (ACL) reconstruction with the hamstring tendon graft takes a long time as the tendon graft needs to heal at the site of the bone tendon integration in the created bone tunnels. Several reports have shown the therapeutic effects of simvastatin on bone formation with neovascularization. The aim of this study was to test the hypothesis that enhanced angiogenesis and osteogenesis by locally applied simvastatin promotes tendon-bone healing after ACL reconstruction. METHODS: Rabbits received ACL reconstruction with hamstring tendon graft and were implanted with either simvastatin-conjucated gelatin hydrogel or gelatin hydrogel alone in their bone tunnels, and then bone regeneration and neovascularization at tendon-bone interface and biomechanical properties were assessed. RESULTS: Histological analysis at week 2 demonstrated that tendon-bone healing was significantly greater with angiogenesis and osteogenesis in the simvastatin treated group than in the control group. Computed tomography at week 2 and 4 showed a significantly smaller tibial bone tunnel in the simvastatin treated group. Biomechanical testing at week 2 demonstrated a significant increase in ultimate failure load in the simvastatin treated group. CONCLUSIONS: This study suggested that local administration of low dose simvastatin-conjugated gelatin hydrogel promotes the tendon-bone healing via its effect on both angiogenesis and osteogenesis at an early phase in a rabbit model but does not affects biomechanical property in long-term after ACL reconstruction.
Shinya Oka; Tomoyuki Matsumoto; Seiji Kubo; Takehiko Matsushita; Hiroshi Sasaki; Yuichiro Nishizawa; Tokio Matsuzaki; Takashi Saito; Kotaro Nishida; Yasuhiko Tabata; Masahiro Kurosaka; Ryosuke Kuroda
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-2
Journal Detail:
Title:  Tissue engineering. Part A     Volume:  -     ISSN:  1937-335X     ISO Abbreviation:  Tissue Eng Part A     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101466659     Medline TA:  Tissue Eng Part A     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Kobe University Graduate School of Medicine, Department of Orthopaedic Surgery, Kobe, Hyogo, Japan;
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