| Local Ischemic Postconditioning during Primary Percutaneous Coronary Intervention: A Meta-Analysis. | |
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MedLine Citation:
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PMID: 23208307 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objectives: To investigate current evidence linking ischemic postconditioning (IPC) to cardioprotection in patients receiving primary percutaneous coronary intervention (PCI). Methods: We performed searches of PubMed, Embase, MEDLINE and Cochrane databases from January 1998 to May 2011 for identifying relevant studies comparing IPC with usual care in patients undergoing primary PCI. A meta-analysis of eligible studies was assessed by Review Manager 5.0. Results: Thirteen studies were eligible. Compared to the control, observed outcomes such as peak creatine kinase [weighted mean difference (WMD) -537.48, 95% confidence interval (CI) -779.32 to -295.65 IU/l], peak creatine kinase-myocardial band (WMD -61.11, 95% CI -76.56 to -45.66 U/l), complete ST-segment resolution (risk ratio 1.38, 95% CI 1.07 to 1.77), blush grade during reflow (WMD 0.64, 95% CI 0.49 to 0.78), corrected TIMI frame count, single-photon emission computed tomography determining infarct size, long-term left ventricular ejection fraction and short-term and long-term wall motion score indexes were improved in IPC group, with less occurrence of heart failure during the 3-month to 3.4-year follow-up. Conclusions: Though current evidence indicates that IPC provides potential cardioprotection to patients receiving primary PCI, larger adequately powered studies should be undertaken to confirm its advantages. |
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Authors:
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Yong Wei; Lei Ruan; Genqing Zhou; Liqun Zhao; Baozhen Qi; Ping Ouyang; Zhimin Jin; Cuntai Zhang; Shaowen Liu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-27 |
Journal Detail:
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Title: Cardiology Volume: 123 ISSN: 1421-9751 ISO Abbreviation: Cardiology Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-12-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: - |
Other Details:
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Languages: ENG Pagination: 225-233 Citation Subset: - |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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