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Local Cytokine Profiles of Patients with Cervical Intraepithelial and Invasive Neoplasia.
MedLine Citation:
PMID:  22749886     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Several studies have suggested that patients with cervical intraepithelial and invasive neoplasia have reduced levels of Th1 cytokines, and increased levels of Th2 cytokines. Thus, the aim of this study was to delineate the immunological profile associated with lesion progression. Biopsies were obtained from 28 patients with low grade cervical intraepithelial lesions (LSILs), 53 patients with high grade cervical intraepithelial lesions (HSILs), 25 patients with invasive cancer (CA), and 20 healthy controls. Levels of IFN-γ, TNF-α, IL-2, IL-4, IL-10, IL-12, TGF-β1 and TGF-β2 were then assayed by RT-PCR and ELISA for each biopsy sample. For LSILs, higher levels of Th1 cytokines were detected, while HSILs were associated with a Th2 cytokine profile. In contrast, CA tissues were associated with the strongest expression of a Treg cytokine profile. In conclusion the most important contribution of these work is identification of the Treg cytokine profile in HPV progression lesions and in combination, these results suggested that tumor progression is dependent on suppression of cellular immunity.
Authors:
Bethânea Crema Peghini; Douglas Reis Abdalla; Ana Cristina Macedo Barcelos; Lívia das Graças Vieito Lombardi Teodoro; Eddie Fernando Candido Murta; Márcia Antoniazi Michelin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-27
Journal Detail:
Title:  Human immunology     Volume:  -     ISSN:  1879-1166     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-7-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8010936     Medline TA:  Hum Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
Affiliation:
Oncology Research Institute - IPON - Federal University of Triangulo Mineiro (UFTM) - Uberaba, MG - Brazil; Discipline of Biochemistry; Discipline of Immunology; Discipline of Gynecology and Obstetrics.
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