| Lobar atrophy in frontotemporal dementia: diagnostic and prognostic implications. | |
| | |
MedLine Citation:
|
PMID: 21222601 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We review the practical importance of lobar atrophy in frontotemporal dementia (FTD), for diagnosis and prognosis. We discuss specific patterns of frontotemporal atrophy that denote clinical and pathological subtypes of FTD (e.g. semantic dementia). We also discuss the unsatisfactory clinical experience of interpreting MRI scans in individual FTD cases, especially the behavioural presentations (without aphasic or motor impairments). This issue is explored by examining the FTD phenocopy concept. Lobar atrophy emerges as a key observation in defining behavioural FTD patients whose symptoms are likely to progress. In a situation where objective clinical data are few, we highlight the importance of applying caution before diagnosing FTD is the absence of visible brain atrophy. |
| | |
Authors:
|
R R Davies; C M Kipps |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Current Alzheimer research Volume: 8 ISSN: 1875-5828 ISO Abbreviation: Curr Alzheimer Res Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-08-17 Completed Date: 2011-12-06 Revised Date: 2012-01-25 |
Medline Journal Info:
|
Nlm Unique ID: 101208441 Medline TA: Curr Alzheimer Res Country: United Arab Emirates |
Other Details:
|
Languages: eng Pagination: 261-5 Citation Subset: IM |
Affiliation:
|
The Walton Centre for Neurology and Neurosurgery, Liverpool, UK. rhys.davies@thewaltoncentre.nhs.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Atrophy Disease Progression Frontal Lobe / pathology* Frontotemporal Dementia / pathology* Humans Prognosis Temporal Lobe / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: FTD and ALS: a tale of two diseases.
Next Document: Regulation of gene expression by TDP-43 and FUS/TLS in frontotemporal lobar degeneration.