Document Detail

Loading sequence plays an important role in enhanced load sensitivity of left ventricular relaxation in conscious dogs with tachycardia-induced cardiomyopathy.
MedLine Citation:
PMID:  8521579     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Left ventricular relaxation rate in the failing heart depends more on the systolic load than in the normal heart. To elucidate the mechanisms for the enhanced load sensitivity of left ventricular relaxation in heart failure, we examined the relative contributions of changes in end-systolic volume and loading sequence to the left ventricular relaxation rate. METHODS AND RESULTS: In seven conscious dogs, the time constant (Td) of left ventricular pressure decay, end-systolic volume, systolic circumferential force, and time to peak force during caval occlusion were compared before and after development of tachycardia-induced heart failure. Rapid ventricular pacing decreased the slope of the end-systolic pressure-volume relation from 4.5 to 2.8 mm Hg/mL (P < .01) and prolonged Td from 33 to 49 ms (P < .01). In normal conditions, caval occlusion reduced end-systolic force (-580 g, P < .01) and end-systolic volume (-7 mL, P < .01) but did not change Td or time to peak force. In heart failure, however, caval occlusion shortened Td (-11 ms, P < .01), with a concomitant decrease in the time to peak force (-30 ms, P < .01), while end-systolic volume and force declined slightly. Consequently, for a comparable reduction in end-systolic force, Td decreased more in heart failure than in normal hearts, suggesting enhanced load sensitivity. Moreover, changes in Td correlated well with those in the time to peak force (r = .79, P < .01) but not with those in end-systolic volume. CONCLUSIONS: Loading sequence rather than elastic recoil seems to play the predominant role in the enhanced load sensitivity of left ventricular relaxation in heart failure.
S Ishizaka; H Asanoi; O Wada; T Kameyama; H Inoue
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  92     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-01-23     Completed Date:  1996-01-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3560-7     Citation Subset:  AIM; IM; S    
Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
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MeSH Terms
Cardiac Pacing, Artificial
Heart Catheterization
Heart Failure / etiology,  physiopathology*
Systole / physiology
Tachycardia, Ventricular / complications*
Time Factors
Ventricular Function, Left / physiology*
Ventricular Pressure / physiology
Comment In:
Circulation. 1995 Dec 15;92(12):3377-80   [PMID:  8521554 ]

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