Document Detail

Loading dose of digoxin in renal failure.
MedLine Citation:
PMID:  7387815     Owner:  NLM     Status:  MEDLINE    
1 Twenty-two dialysis dependent patients received an intravenous loading dose of digoxin of 10 microgram/kg and the mean +/- s.d. serum digoxin concentration 24 h later was 1.5 ng/ml +/- 0.4 (range 0.8--2.1 ng/ml). No evidence of toxicity was observed. 2 The average apparent volume of distribution of digoxin in dialysis dependent patients was found to be reduced by about one third compared with that reported for individuals with normal renal function, but there was great variation. 3 An appropriate intravenous loading dose of digoxin in most patients with advanced renal failure is 10 microgram/kg.
M H Gault; D N Churchill; J Kalra
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  9     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1980 Jun 
Date Detail:
Created Date:  1980-09-28     Completed Date:  1980-09-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  593-7     Citation Subset:  IM    
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MeSH Terms
Digoxin / administration & dosage*,  blood
Electrolytes / blood
Kidney Failure, Acute / metabolism*
Kidney Failure, Chronic / metabolism*
Middle Aged
Time Factors
Reg. No./Substance:
0/Electrolytes; 20830-75-5/Digoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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