Document Detail

Load dependence of simulated central tremor.
MedLine Citation:
PMID:  10326243     Owner:  NLM     Status:  MEDLINE    
Previous studies have argued that tremors of central versus peripheral origin can be distinguished based on their load dependence: the frequency of peripheral tremor decreases when a weight is added to the tremulous limb, while the frequency of central tremors remains unchanged. The present study scrutinizes the latter statement. We simulated central tremor using a simple network of coupled neural oscillators, which receives proprioceptive feedback from the motor periphery. The network produced a self-sustained, stable oscillation. When the gain of proprioceptive feedback was high, oscillation frequency decreased in the presence of an inertial load. When the gain was low, the oscillation frequency was load independent. We conclude that load dependence is not an exclusive property of peripheral tremors but may be found in tremors of central origin as well. Therefore, the load test is not sufficient to reject a central tremor origin.
N Wenderoth; O Bock
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological cybernetics     Volume:  80     ISSN:  0340-1200     ISO Abbreviation:  Biol Cybern     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-05-28     Completed Date:  1999-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7502533     Medline TA:  Biol Cybern     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  285-90     Citation Subset:  IM    
Department of Physiology, German Sport University, Cologne, Germany.
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MeSH Terms
Central Nervous System / physiopathology
Models, Biological*
Peripheral Nervous System / physiopathology
Tremor / physiopathology*

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