Document Detail

LncRNAs have a say in protein translation.
MedLine Citation:
PMID:  23208421     Owner:  NLM     Status:  MEDLINE    
In a recent paper published in Nature, Carrieri et al. have identified in mouse a neuron-specific antisense lncRNA transcribed in the opposite strand of Uchl1 mRNA. Antisense Uchl1 specifically promotes the translation of UCHL1 under rapamycin treatment. To do so, the lncRNA only requires a SINEB2 repeat and a small region with sequence complementarity to the regulated mRNA.
Maite Huarte
Publication Detail:
Type:  Comment; Journal Article     Date:  2012-12-04
Journal Detail:
Title:  Cell research     Volume:  23     ISSN:  1748-7838     ISO Abbreviation:  Cell Res.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-01     Completed Date:  2013-09-13     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  9425763     Medline TA:  Cell Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  449-51     Citation Subset:  IM    
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MeSH Terms
Protein Biosynthesis / genetics*
RNA, Antisense / metabolism*
Short Interspersed Nucleotide Elements / genetics*
Ubiquitin Thiolesterase / genetics*,  metabolism*
Reg. No./Substance:
0/RNA, Antisense; EC Thiolesterase
Comment On:
Nature. 2012 Nov 15;491(7424):454-7   [PMID:  23064229 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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