| Lmx1b is required for murine trabecular meshwork formation and for maintenance of corneal transparency. | |
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MedLine Citation:
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PMID: 20568247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies of Lmx1b have shown that it is required for anterior segment formation during embryonic development and that reduction of Lmx1b may contribute to elevated intraocular pressure in the adult. However, whether Lmx1b is required for formation of anterior segment tissues that are associated with regulation of intraocular pressure has not been addressed due to the perinatal lethality of Lmx1b null allele. Here we use conditional deletion strategies to circumvent perinatal lethality. Our results indicate that Lmx1b is required in neural crest-derived periocular mesenchyme for formation of anterior segment tissues, including trabecular meshwork, a critical regulator of intraocular pressure. Furthermore, we show that Lmx1b is essential to maintain proper functioning of those tissues in the adult. Taken together, our results are the first to link a specific transcription factor to trabecular meshwork formation and the first to demonstrate specific requirements for Lmx1b in maintaining the integrity of adult anterior segment. |
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Authors:
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Pu Liu; Randy L Johnson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental dynamics : an official publication of the American Association of Anatomists Volume: 239 ISSN: 1097-0177 ISO Abbreviation: Dev. Dyn. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-11-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9201927 Medline TA: Dev Dyn Country: United States |
Other Details:
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Languages: eng Pagination: 2161-71 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cornea / physiology* Homeodomain Proteins / physiology* Intraocular Pressure Mesoderm / cytology Mice Neural Crest / cytology Trabecular Meshwork / growth & development* Transcription Factors / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Homeodomain Proteins; 0/LIM homeobox transcription factor 1 beta; 0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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