Document Detail


Lixivaptan: a vasopressin receptor antagonist for the treatment of hyponatremia.
MedLine Citation:
PMID:  23151986     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Hyponatremia, the most common electrolyte disorder encountered in clinical practice, is associated with significant morbidity and mortality. The introduction of medications that specifically antagonize the vasopressin V2 receptor (vaptans) has provided a safe and effective means of therapy. Lixivaptan is the newest of these agents that reliably increase serum sodium levels in patients with euvolemic hyponatremia. However, significant questions remain regarding the specific indications for vaptans, and their potential impact on morbidity and mortality associated with hyponatremia.
Authors:
Mitchell H Rosner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  82     ISSN:  1523-1755     ISO Abbreviation:  Kidney Int.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1154-6     Citation Subset:  IM    
Affiliation:
Divison of Nephrology, University of Virginia Health System, Charlottesville, Virginia, USA.
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