| Living related kidney transplantation without calcineurin inhibitors: initial experience in a Mexican center. | |
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MedLine Citation:
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PMID: 17164728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We performed a prospective randomized trial comparing sirolimus/mycophenolate mofetil (MMF)/prednisone to cyclosporine/MMF/prednisone and selected induction therapy with basiliximab. Twenty patients received sirolimus (10 mg loading dose followed by 3 mg/m body surface area/day, keeping 24-hr trough levels at 10-15 ng/mL for six months and 5-10 ng/mL thereafter. Twenty-one patients began cyclosporine (4 to 8 mg/kg/day, keeping 12-hour trough levels at 150-300 ng/mL for 6 months and 100-200 ng/mL afterwards). Mean follow up was 15.8 months. One-year patient and graft survival was similar in both groups (>90%). Acute rejection rate was 16.6% in the sirolimus group and 5.2% in the cyclosporine group (P=NS). There were no differences in mean serum creatinine between groups. No patients who received basiliximab and had sirolimus target levels suffered acute rejection at one year. The sirolimus group had significantly higher cholesterol and triglycerides. A calcineurin inhibitor-free regimen using sirolimus produces comparable one-year transplant outcomes in living related kidney transplants compared to a calcineurin inhibitor regimen. |
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Authors:
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Gustavo Martinez-Mier; Marco T Mendez-Lopez; Luis F Budar-Fernandez; Jorge Estrada-Oros; Regino Franco-Abaroa; Esteban George-Micelli; Luis Rios-Martinez; Gustavo F Mendez-Machado |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Transplantation Volume: 82 ISSN: 0041-1337 ISO Abbreviation: Transplantation Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-13 Completed Date: 2007-03-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0132144 Medline TA: Transplantation Country: United States |
Other Details:
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Languages: eng Pagination: 1533-6 Citation Subset: IM |
Affiliation:
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Department of Organ Transplantation, IMSS Adolfo Ruiz Cortines National Medical Center, Veracruz, Mexico. gmtzmier@ver.megared.net.mx |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anti-Inflammatory Agents / therapeutic use* Blood Chemical Analysis Calcineurin / antagonists & inhibitors Drug Therapy, Combination Female Graft Rejection / prevention & control* Graft Survival Humans Immunosuppressive Agents / therapeutic use* Kidney / physiology Kidney Transplantation* Living Donors* Male Mexico Prednisone / therapeutic use* Prospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Immunosuppressive Agents; 53-03-2/Prednisone; EC 3.1.3.16/Calcineurin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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