Document Detail


Living well with medical comorbidities: a biopsychosocial perspective.
MedLine Citation:
PMID:  22377799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We take a biopsychosocial perspective on age-related diseases by examining psychological correlates of having multiple chronic conditions and determining whether positive psychological functioning predicts advantageous profiles of biological risk factors.
METHOD: Respondents to the national survey of Midlife in the United States who participated in clinical assessments of health and biological processes (n = 998) provided information on chronic medical conditions and multiple domains of psychological functioning. Serum concentrations of interleukin-6 (IL-6) and C-reactive protein (CRP) were determined from fasting blood samples.
RESULTS: Life satisfaction declined with increasing comorbidity while negative affect increased. In contrast, positive affect, purpose in life, and positive relations with others were unrelated to comorbidity status. Significant interactions showed that although IL-6 and CRP increased with increasing number of chronic conditions, respondents with higher levels of purpose in life, positive relations with others, and (in the case of CRP) positive affect had lower levels of inflammation compared with those with lower well-being scores.
DISCUSSION: The results suggest that many older adults with medical comorbidities maintain high levels of positive psychological functioning that are in turn linked to better profiles of biological disease risk.
Authors:
Elliot M Friedman; Carol D Ryff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study     Date:  2012-02-29
Journal Detail:
Title:  The journals of gerontology. Series B, Psychological sciences and social sciences     Volume:  67     ISSN:  1758-5368     ISO Abbreviation:  J Gerontol B Psychol Sci Soc Sci     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-12     Completed Date:  2012-11-13     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  9508483     Medline TA:  J Gerontol B Psychol Sci Soc Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  535-44     Citation Subset:  AIM; IM    
Affiliation:
CorreInstitute on Aging, University of Wisconsin, Madison, 624 WARF Building, 610 North Walnut Street, Madison, WI 53726, USA. friedman1@wisc.edu
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MeSH Terms
Descriptor/Qualifier:
Affective Symptoms / blood,  psychology
Aged
C-Reactive Protein / metabolism
Chronic Disease / psychology*
Comorbidity
Diseases in Twins / blood,  psychology
Female
Humans
Interleukin-6 / blood
Interpersonal Relations
Longitudinal Studies
Male
Middle Aged
Motivation
Quality of Life / psychology*
Risk Factors
Statistics as Topic
United States
Grant Support
ID/Acronym/Agency:
K01 AG029381/AG/NIA NIH HHS; K01-AG029381/AG/NIA NIH HHS; P01-AG020166/AG/NIA NIH HHS; UL1 TR000427/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Interleukin-6; 9007-41-4/C-Reactive Protein
Comments/Corrections

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