Document Detail


Liver visfatin expression in morbidly obese patients with nonalcoholic fatty liver disease undergoing bariatric surgery.
MedLine Citation:
PMID:  21225497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Visfatin has been identified as a new adipokine with proinflammatory and immunomodulating properties. It seems to interfere with immune and fibrogenic process in nonalcoholic fatty liver disease (NAFLD). The aim was to assess visfatin expression in the liver tissue and its association with biochemical parameters and morphological features in NAFLD patients.
MATERIAL AND METHODS: The study included 40 severely obese patients with NAFLD who underwent intraoperative wedge liver biopsy during a bariatric operation. Immunohistochemical assay was carried out with the use of a visfatin mice monoclonal antibody.
RESULTS: Visfatin expression in the liver was observed in all patients. The expression was significantly higher in patients with fibrosis (p = 0.036) and was positively correlated with the fibrosis stage (r = 0.52, p = 0.03). There was no difference between patient with nonalcoholic steatohepatitis (NASH) and simple steatosis (p = 0.54). Inflammatory activity and NAS (NAFLD Activity Score) score were not associated with visfatin expression. There was a tendency of more evident visfatin liver expression in morbidly obese patients with diabetes mellitus.
CONCLUSION: Our study showed a positive association between visfatin and the fibrosis stage in NAFLD. This observation suggests a potential role of this adipokine in the pathogenesis and progression of NAFLD. Visfatin expression does not seem to be associated with liver steatosis and inflammation.
Authors:
Michał Kukla; Monika Ciupińska-Kajor; Maciej Kajor; Mariusz Wyleżoł; Krystyna Żwirska-Korczala; Marek Hartleb; Agnieszka Berdowska; Włodzimierz Mazur
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Polish journal of pathology : official journal of the Polish Society of Pathologists     Volume:  61     ISSN:  1233-9687     ISO Abbreviation:  Pol J Pathol     Publication Date:  2010  
Date Detail:
Created Date:  2011-01-12     Completed Date:  2011-06-16     Revised Date:  2012-01-17    
Medline Journal Info:
Nlm Unique ID:  9437432     Medline TA:  Pol J Pathol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  147-53     Citation Subset:  IM    
Affiliation:
Department of Physiology in Zabrze, Medical Univeristy of Silesia, Katowice. kuklamich@poczta.onet.pl
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MeSH Terms
Descriptor/Qualifier:
Adult
Bariatric Surgery*
Cytokines / metabolism*
Fatty Liver / complications,  metabolism,  pathology,  surgery
Female
Hepatocytes / metabolism,  pathology
Humans
Immunohistochemistry
Liver / metabolism*
Liver Cirrhosis / complications,  metabolism,  pathology
Male
Middle Aged
Nicotinamide Phosphoribosyltransferase / metabolism*
Obesity, Morbid / complications,  metabolism*,  pathology,  surgery
Chemical
Reg. No./Substance:
0/Cytokines; EC 2.4.2.12/Nicotinamide Phosphoribosyltransferase; EC 2.4.2.12/nicotinamide phosphoribosyltransferase, human

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