Document Detail

Liver tumors in neonates and very young infants: diagnostic pitfalls and therapeutic problems.
MedLine Citation:
PMID:  7542025     Owner:  NLM     Status:  MEDLINE    
We report on 26 infants under 3 months of age with various liver tumors, who were treated in our hospital since 1977 and/or registered in the German Cooperative Pediatric Liver Tumor Study HB-89. 17 of these had an infantile hemangioendothelioma (inf HE), 7 a hepatoblastoma (HB), one a mesenchymal hamartoma (mes H) and one a neuroblastoma stage IV-S (Nbl). Polyhydramnios occurred in 5 cases of inf HE, in one associated with hydrops fetalis. This led to a preterm delivery of 4 infants. 7 infants with a large inf HE suffered from high output congestive heart insufficiency, 2 additionally from a Kasabach-Merritt-syndrome. Serum alpha-fetoprotein was within normal range of age in all infants except in one HB patient. Neuron-specific enolase was clearly elevated in the Nbl patient and slightly above normal range in one inf HE and 3 HB patients. Other tumor markers and platelet counts were not indicative of diagnosis. Also imaging techniques as ultrasonography, CT and angiography were not always reliable in differentiating the tumors. In 2 cases the initial histological diagnosis of an HB had to be corrected for an inf HE. In 6 children the tumors were initially treated under a wrong assumption: 4 tumors as an HB instead of an inf HE, one as an inf HE instead of a Nbl IV-S and one as a focal nodular hyperplasia of the liver instead of an HB. 7 not resected inf HEs (Dehner type I) showed spontaneous regression after 6 months to 3 years. One inf HE type II relapsed twice after resection.(ABSTRACT TRUNCATED AT 250 WORDS)
D von Schweinitz; S Glüer; H Mildenberger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie     Volume:  5     ISSN:  0939-7248     ISO Abbreviation:  Eur J Pediatr Surg     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-08-18     Completed Date:  1995-08-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9105263     Medline TA:  Eur J Pediatr Surg     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  72-6     Citation Subset:  IM    
Department of Pediatric Surgery, Medical School Hannover.
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MeSH Terms
Child, Preschool
Hamartoma / diagnosis
Hemangioendothelioma / diagnosis
Infant, Newborn
Liver Diseases / diagnosis
Liver Neoplasms / diagnosis*,  therapy*
Neuroblastoma / diagnosis
Phosphopyruvate Hydratase / analysis
Platelet Count
Tumor Markers, Biological / analysis
alpha-Fetoproteins / analysis
Reg. No./Substance:
0/Tumor Markers, Biological; 0/alpha-Fetoproteins; EC Hydratase

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