| Liver tumors in neonates and very young infants: diagnostic pitfalls and therapeutic problems. | |
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MedLine Citation:
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PMID: 7542025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report on 26 infants under 3 months of age with various liver tumors, who were treated in our hospital since 1977 and/or registered in the German Cooperative Pediatric Liver Tumor Study HB-89. 17 of these had an infantile hemangioendothelioma (inf HE), 7 a hepatoblastoma (HB), one a mesenchymal hamartoma (mes H) and one a neuroblastoma stage IV-S (Nbl). Polyhydramnios occurred in 5 cases of inf HE, in one associated with hydrops fetalis. This led to a preterm delivery of 4 infants. 7 infants with a large inf HE suffered from high output congestive heart insufficiency, 2 additionally from a Kasabach-Merritt-syndrome. Serum alpha-fetoprotein was within normal range of age in all infants except in one HB patient. Neuron-specific enolase was clearly elevated in the Nbl patient and slightly above normal range in one inf HE and 3 HB patients. Other tumor markers and platelet counts were not indicative of diagnosis. Also imaging techniques as ultrasonography, CT and angiography were not always reliable in differentiating the tumors. In 2 cases the initial histological diagnosis of an HB had to be corrected for an inf HE. In 6 children the tumors were initially treated under a wrong assumption: 4 tumors as an HB instead of an inf HE, one as an inf HE instead of a Nbl IV-S and one as a focal nodular hyperplasia of the liver instead of an HB. 7 not resected inf HEs (Dehner type I) showed spontaneous regression after 6 months to 3 years. One inf HE type II relapsed twice after resection.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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D von Schweinitz; S Glüer; H Mildenberger |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie Volume: 5 ISSN: 0939-7248 ISO Abbreviation: Eur J Pediatr Surg Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-08-18 Completed Date: 1995-08-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9105263 Medline TA: Eur J Pediatr Surg Country: GERMANY |
Other Details:
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Languages: eng Pagination: 72-6 Citation Subset: IM |
Affiliation:
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Department of Pediatric Surgery, Medical School Hannover. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child, Preschool Hamartoma / diagnosis Hemangioendothelioma / diagnosis Humans Infant Infant, Newborn Liver Diseases / diagnosis Liver Neoplasms / diagnosis*, therapy* Neuroblastoma / diagnosis Phosphopyruvate Hydratase / analysis Platelet Count Tumor Markers, Biological / analysis alpha-Fetoproteins / analysis |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological; 0/alpha-Fetoproteins; EC 4.2.1.11/Phosphopyruvate Hydratase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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