| Liver transplantation using non-heart-beating donors: Belgian experience. | |
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MedLine Citation:
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PMID: 17580167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mortality on liver transplantation (OLT) waiting lists has increased dramatically. Until recently, non-heart-beating donors (NHBD) were not considered suitable for OLT, because of a higher risk of primary graft nonfunction (PNF) and biliary strictures. However, recent experimental/clinical evidence has indicated that NHBD-OLT is feasible when the period of warm ischemia is short. PURPOSE: To characterize the results of NHBD-OLT in Belgium, a survey was sent to all Belgian OLT centers. RESULTS: Between January 2003 and November 2005, 16 livers originating from NHBD were procured and transplanted. The mean donor age was 48.8 years, including 9 males and 7 females with mean time of stop-therapy to cardiac arrest being 18 minutes and from cardiac arrest to liver cold perfusion, 10.5 minutes. Mean recipient age was 52.2 years including 12 males and 4 females. Mean cold ischemia time was 7 hours 15 minutes. No PNF requiring re-OLT was observed. Mean post-OLT peak transaminase was 2209 IU/L, which was higher among imported versus locally procured grafts. Biliary complications occurred in 6 patients requiring re-OLT (n = 2), endoscopic treatment (n = 2), surgical treatment (n = 1), or left untreated (n = 1). These tended to be more frequent after prolonged warm ischemia. Graft and patient survivals were 62.5% and 81.3%, respectively, with a follow-up of 3 to 36 months. CONCLUSION: This survey showed acceptable graft/patient survivals after NHBD-LT. The NHBD-liver grafts suffered a high rate of ischemic injury and biliary complications and therefore should be used carefully, namely with no additional donor risk factors, lower risk recipients, and short cold/warm ischemia. |
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Authors:
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D Monbaliu; F Van Gelder; R Troisi; B de Hemptinne; J Lerut; R Reding; J de Ville de Goyet; O Detry; A De Roover; P Honore; V Donckier; M Gelin; D Ysebaert; R Aerts; W Coosemans; J Pirenne |
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Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: Transplantation proceedings Volume: 39 ISSN: 0041-1345 ISO Abbreviation: Transplant. Proc. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-20 Completed Date: 2007-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
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Languages: eng Pagination: 1481-4 Citation Subset: IM |
Affiliation:
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Abdominal Transplant Surgery Department, University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium. Diethard.Monbaliu@uz.kuleuven.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Belgium Female Heart Arrest* Humans Liver Function Tests Liver Transplantation / mortality, physiology* Male Middle Aged Retrospective Studies Survival Analysis Tissue Donors / statistics & numerical data Waiting Lists |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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