Document Detail

Liver transplantation using non-heart-beating donors: Belgian experience.
MedLine Citation:
PMID:  17580167     Owner:  NLM     Status:  MEDLINE    
Mortality on liver transplantation (OLT) waiting lists has increased dramatically. Until recently, non-heart-beating donors (NHBD) were not considered suitable for OLT, because of a higher risk of primary graft nonfunction (PNF) and biliary strictures. However, recent experimental/clinical evidence has indicated that NHBD-OLT is feasible when the period of warm ischemia is short. PURPOSE: To characterize the results of NHBD-OLT in Belgium, a survey was sent to all Belgian OLT centers. RESULTS: Between January 2003 and November 2005, 16 livers originating from NHBD were procured and transplanted. The mean donor age was 48.8 years, including 9 males and 7 females with mean time of stop-therapy to cardiac arrest being 18 minutes and from cardiac arrest to liver cold perfusion, 10.5 minutes. Mean recipient age was 52.2 years including 12 males and 4 females. Mean cold ischemia time was 7 hours 15 minutes. No PNF requiring re-OLT was observed. Mean post-OLT peak transaminase was 2209 IU/L, which was higher among imported versus locally procured grafts. Biliary complications occurred in 6 patients requiring re-OLT (n = 2), endoscopic treatment (n = 2), surgical treatment (n = 1), or left untreated (n = 1). These tended to be more frequent after prolonged warm ischemia. Graft and patient survivals were 62.5% and 81.3%, respectively, with a follow-up of 3 to 36 months. CONCLUSION: This survey showed acceptable graft/patient survivals after NHBD-LT. The NHBD-liver grafts suffered a high rate of ischemic injury and biliary complications and therefore should be used carefully, namely with no additional donor risk factors, lower risk recipients, and short cold/warm ischemia.
D Monbaliu; F Van Gelder; R Troisi; B de Hemptinne; J Lerut; R Reding; J de Ville de Goyet; O Detry; A De Roover; P Honore; V Donckier; M Gelin; D Ysebaert; R Aerts; W Coosemans; J Pirenne
Related Documents :
19414637 - Improved patient survival using a modified resuscitation protocol for out-of-hospital c...
3986977 - Predictive survival models for resuscitated victims of out-of-hospital cardiac arrest w...
1247777 - Importance of patient selection in evaluating a cardiac ambulance service.
11845547 - Postresuscitation myocardial dysfunction.
14970107 - Serum amyloid a as a predictor of coronary artery disease and cardiovascular outcome in...
11825727 - Plasma levels and vascular effects of endothelin and big endothelin in patients with st...
Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Transplantation proceedings     Volume:  39     ISSN:  0041-1345     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-20     Completed Date:  2007-09-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1481-4     Citation Subset:  IM    
Abdominal Transplant Surgery Department, University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Heart Arrest*
Liver Function Tests
Liver Transplantation / mortality,  physiology*
Middle Aged
Retrospective Studies
Survival Analysis
Tissue Donors / statistics & numerical data
Waiting Lists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Long-term analysis of primary nonfunction in liver transplant recipients.
Next Document:  Intraoperative assessment of liver organ condition by the procurement surgeon.